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NLRP3 inflammasome-mediated, IL-1β-dependent inflammatory responses drive steroid-resistant asthma

Jay Horvat, Richard Kim, James Pinkerton, Ama-Tawiah Essilfie, Avril Robertson, Katherine Baines, Jemma Mayall, Malcolm Starkey, Peter Wark, Peter Gibson, Luke O'Neill, Matthew Cooper, Philip Hansbro
European Respiratory Journal 2016 48: PA564; DOI: 10.1183/13993003.congress-2016.PA564
Jay Horvat
1Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South WalesAustralia
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Richard Kim
1Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South WalesAustralia
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James Pinkerton
1Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South WalesAustralia
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Ama-Tawiah Essilfie
1Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South WalesAustralia
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Avril Robertson
2Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QueenslandAustralia
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Katherine Baines
1Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South WalesAustralia
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Jemma Mayall
1Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South WalesAustralia
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Malcolm Starkey
1Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South WalesAustralia
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Peter Wark
1Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South WalesAustralia
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Peter Gibson
1Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South WalesAustralia
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Luke O'Neill
3School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
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Matthew Cooper
2Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QueenslandAustralia
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Philip Hansbro
1Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South WalesAustralia
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Article Information

vol. 48 no. suppl 60
DOI 
https://doi.org/10.1183/13993003.congress-2016.PA564

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Published online November 8, 2016.

Copyright & Usage 
Copyright ©the authors 2016

Author Information

  1. Jay Horvat1,
  2. Richard Kim1,
  3. James Pinkerton1,
  4. Ama-Tawiah Essilfie1,
  5. Avril Robertson2,
  6. Katherine Baines1,
  7. Jemma Mayall1,
  8. Malcolm Starkey1,
  9. Peter Wark1,
  10. Peter Gibson1,
  11. Luke O'Neill3,
  12. Matthew Cooper2 and
  13. Philip Hansbro1
  1. 1Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South WalesAustralia
  2. 2Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QueenslandAustralia
  3. 3School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

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NLRP3 inflammasome-mediated, IL-1β-dependent inflammatory responses drive steroid-resistant asthma
Jay Horvat, Richard Kim, James Pinkerton, Ama-Tawiah Essilfie, Avril Robertson, Katherine Baines, Jemma Mayall, Malcolm Starkey, Peter Wark, Peter Gibson, Luke O'Neill, Matthew Cooper, Philip Hansbro
European Respiratory Journal Sep 2016, 48 (suppl 60) PA564; DOI: 10.1183/13993003.congress-2016.PA564

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NLRP3 inflammasome-mediated, IL-1β-dependent inflammatory responses drive steroid-resistant asthma
Jay Horvat, Richard Kim, James Pinkerton, Ama-Tawiah Essilfie, Avril Robertson, Katherine Baines, Jemma Mayall, Malcolm Starkey, Peter Wark, Peter Gibson, Luke O'Neill, Matthew Cooper, Philip Hansbro
European Respiratory Journal Sep 2016, 48 (suppl 60) PA564; DOI: 10.1183/13993003.congress-2016.PA564
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