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Comparison analysis of malignant and tuberculous pleural fluid using proteomic method

Chang Youl Lee, Ji Young Hong, Myung-Goo Lee, Seung Hun Jang, In-Bum Suh
European Respiratory Journal 2016 48: PA5087; DOI: 10.1183/13993003.congress-2016.PA5087
Chang Youl Lee
1Pulmonary, Allergy and Critical Care Medicine, Hallym University Medical Center, Chuncheon, KangwonRepublic of Korea
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Ji Young Hong
1Pulmonary, Allergy and Critical Care Medicine, Hallym University Medical Center, Chuncheon, KangwonRepublic of Korea
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Myung-Goo Lee
1Pulmonary, Allergy and Critical Care Medicine, Hallym University Medical Center, Chuncheon, KangwonRepublic of Korea
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Seung Hun Jang
1Pulmonary, Allergy and Critical Care Medicine, Hallym University Medical Center, Chuncheon, KangwonRepublic of Korea
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In-Bum Suh
2Laboratory Medicine, Kangwon National University, Chuncheon, KangwonRepublic of Korea
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Abstract

Background and Aim: A pleural effusion, an accumulation of fluid in the pleural space, usually occurs in patients when the rate of fluid formation exceeds the rate of fluid removal. Interest in the diagnostic utility of proteins present in the pleural effusion has recently increased. The differential diagnosis of tuberculous pleurisy and malignant pleural effusion is a difficult task in high tuberculous prevalence areas. The aim of the present study is to identify novel biomarkers for the diagnosis of pleural fluid using proteomics technology.

Methods: We analyzed the proteins in pleural fluid from patients using a technique that combined 2D liquid-phase electrophoresis (2-DE), matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS). Patients with transudative pleural effusions, tuberculous, or malignant effusions were enrolled in the study.

Results:  We identified a total of 10 proteins with high confidence. Bioinformatics analysis of the MS data identified pathologically relevant proteins and potential diagnostic markers for tuberculous pleurisy and malignant pleural effusion associated with lung cancer, including trasthyretin, haptoglobin, metastasis-associated protein(MTA)1, t-complex protein 1, Fibroblast growth factor-binding protein 1, human ceruloplasmin, Lysozyme precursor, Gelsolin, Clusterin C complement lysis inhibitor, and Peroxirexdoxin 3.

Conclusion: These findings will aid in the development of novel diagnostic tools for tuberculous pleurisy and malignant pleural effusion of lung cancer and also provide new insight into the diverse functions of proteins in tuberculosis and cancer pathogenesis.

  • Lung cancer / Oncology
  • Tuberculosis - diagnosis
  • Pleura
  • Copyright ©the authors 2016
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Comparison analysis of malignant and tuberculous pleural fluid using proteomic method
Chang Youl Lee, Ji Young Hong, Myung-Goo Lee, Seung Hun Jang, In-Bum Suh
European Respiratory Journal Sep 2016, 48 (suppl 60) PA5087; DOI: 10.1183/13993003.congress-2016.PA5087

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Comparison analysis of malignant and tuberculous pleural fluid using proteomic method
Chang Youl Lee, Ji Young Hong, Myung-Goo Lee, Seung Hun Jang, In-Bum Suh
European Respiratory Journal Sep 2016, 48 (suppl 60) PA5087; DOI: 10.1183/13993003.congress-2016.PA5087
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More in this TOC Section

  • A comparative study of conventional cytology and cell block method in the diagnosis of pleural effusion
  • Comparison between mesothelin and fibulin-3 detection in pleural malignant mesothelioma (MPM) patients
  • An examination of the factors for successful pleurodesis against malignant pleural effusion (MPE)
Show more 11.2 Pleural and Mediastinal Malignancies

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