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An examination of the factors for successful pleurodesis against malignant pleural effusion (MPE)

Eriko Suzuki, Takeda Yuichiro, Sugiyama Haruhito, Hojo Masayuki, Izumi Shinyu, Ikura Motokazu, Naka Go, Suzuki Manabu, Kobayashi Konomi, Shiozawa Ayako, Yamamoto Shota, Suzuki Tomoyuki, Sakamoto Keita
European Respiratory Journal 2016 48: PA5085; DOI: 10.1183/13993003.congress-2016.PA5085
Eriko Suzuki
1Pulmonary Medicine, National Center for Global Health and Medicine, Tokyo, Japan
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Takeda Yuichiro
1Pulmonary Medicine, National Center for Global Health and Medicine, Tokyo, Japan
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Sugiyama Haruhito
1Pulmonary Medicine, National Center for Global Health and Medicine, Tokyo, Japan
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Hojo Masayuki
1Pulmonary Medicine, National Center for Global Health and Medicine, Tokyo, Japan
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Izumi Shinyu
1Pulmonary Medicine, National Center for Global Health and Medicine, Tokyo, Japan
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Ikura Motokazu
1Pulmonary Medicine, National Center for Global Health and Medicine, Tokyo, Japan
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Naka Go
1Pulmonary Medicine, National Center for Global Health and Medicine, Tokyo, Japan
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Suzuki Manabu
1Pulmonary Medicine, National Center for Global Health and Medicine, Tokyo, Japan
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Kobayashi Konomi
1Pulmonary Medicine, National Center for Global Health and Medicine, Tokyo, Japan
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Shiozawa Ayako
1Pulmonary Medicine, National Center for Global Health and Medicine, Tokyo, Japan
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Yamamoto Shota
1Pulmonary Medicine, National Center for Global Health and Medicine, Tokyo, Japan
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Suzuki Tomoyuki
1Pulmonary Medicine, National Center for Global Health and Medicine, Tokyo, Japan
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Sakamoto Keita
1Pulmonary Medicine, National Center for Global Health and Medicine, Tokyo, Japan
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Abstract

Background: OK-432 has been widely used in Japan for pleurodesis against MPE. Recently, TALC was able to use for pleurodesis against MPE under approval of Japanese medical insurance.

Aim: To examine clinical factors for successful pleurodesis.

Methods: We reviewed the medical record of patients who underwent pleurodesis against MPE from September 2010 to January 2016. A case without recurrent MPE during 30 days after the procedure was defined as a successful one. We also analyzed patient characteristics and adverse events.

Results: Fifty nine trials of plurodesis for a total of 46 patients were performed during the period. The median age of patients was 70 (45 - 97) years old, male / female = 27 / 19, PS 0 / 1 / 2-3 / 4 = 2 / 39 / 17 / 1. Lung cancer, pleural mesothelioma, thymic cancer, and others were 37, 4, 1, and 4, respectively. Sixteen patients had TALC, 8 had OK-432, and 34 had OK-432 with minocycline. Two patients underwent pleurodesis for three times and 9 for twice, respectively. Five patients accomplished the procedure without removing the thoracic tube. The success rate was 31 % (5 / 16) in TALC group, 37.5 % (3 / 8) in OK-432 group, and 79 % (27 / 34) in OK-432 with minocycline group.

Conclusion: In this study, OK-432 with minocycline group achieved high success rate of pleurodesis. We estimate that effective pleurodesis was provided when stronger inflammation happened to pleura by adding Minocycline to OK-432. As there is a deflection in the number of cases, we intend to perform a further research in the future. We are going to perform multivariate analysis to find clinical useful factors for successful pleurodesis against MPE.

  • Lung cancer / Oncology
  • Pleura
  • Palliative care
  • Copyright ©the authors 2016
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An examination of the factors for successful pleurodesis against malignant pleural effusion (MPE)
Eriko Suzuki, Takeda Yuichiro, Sugiyama Haruhito, Hojo Masayuki, Izumi Shinyu, Ikura Motokazu, Naka Go, Suzuki Manabu, Kobayashi Konomi, Shiozawa Ayako, Yamamoto Shota, Suzuki Tomoyuki, Sakamoto Keita
European Respiratory Journal Sep 2016, 48 (suppl 60) PA5085; DOI: 10.1183/13993003.congress-2016.PA5085

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An examination of the factors for successful pleurodesis against malignant pleural effusion (MPE)
Eriko Suzuki, Takeda Yuichiro, Sugiyama Haruhito, Hojo Masayuki, Izumi Shinyu, Ikura Motokazu, Naka Go, Suzuki Manabu, Kobayashi Konomi, Shiozawa Ayako, Yamamoto Shota, Suzuki Tomoyuki, Sakamoto Keita
European Respiratory Journal Sep 2016, 48 (suppl 60) PA5085; DOI: 10.1183/13993003.congress-2016.PA5085
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