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Budesonide/formoterol maintenance and reliever therapy in adolescent patients with asthma

Hans Bisgaard, Dan Lythgoe, Carin Jorup
European Respiratory Journal 2016 48: PA4903; DOI: 10.1183/13993003.congress-2016.PA4903
Hans Bisgaard
1Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen &, Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark
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Dan Lythgoe
2Phastar, Phastar, Chiswick, United Kingdom
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Carin Jorup
3AstraZeneca R&D, AstraZeneca R&D, Gothenburg, Sweden
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Abstract

BACKGROUND: Adolescent patients with asthma are not thought to differ from adults in terms of clinical treatment efficacy.

AIM AND OBJECTIVE: This analysis of 6 double-blind studies (6–12 months) assessed the efficacy/safety of budesonide/formoterol (BUD/FORM) maintenance and reliever therapy (MART) in adolescent patients (12–17 yrs) with asthma.

METHODS: BUD/FORM MART was compared with active comparators (Figure) for time to first severe exacerbation (primary endpoint, except STEAM) and other efficacy parameters. Severe exacerbations were defined as hospitalisation/emergency treatment due to asthma worsening and need for oral steroids for asthma. Safety was assessed by adverse event (AE) type/incidence.

RESULTS: Overall, 1845 adolescent patients were included in the individual study efficacy population. BUD/FORM MART was similar to, or more effective than, comparators across all studies for time to first severe exacerbation, with comparable outcomes for adolescents and adults (Figure). Adult/adolescent patients using BUD/FORM MART received a lower mean daily dose of inhaled corticosteroid versus comparators, when study design allowed. AE type/incidence were similar for adults and adolescents on BUD/FORM MART versus comparators across studies.

CONCLUSIONS: The efficacy and safety of BUD/FORM MART in adolescent asthma patients is similar to that in adults.

FUNDING: AstraZeneca

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  • Asthma - management
  • Exacerbation
  • Adolescents
  • Copyright ©the authors 2016
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Budesonide/formoterol maintenance and reliever therapy in adolescent patients with asthma
Hans Bisgaard, Dan Lythgoe, Carin Jorup
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4903; DOI: 10.1183/13993003.congress-2016.PA4903

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Budesonide/formoterol maintenance and reliever therapy in adolescent patients with asthma
Hans Bisgaard, Dan Lythgoe, Carin Jorup
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4903; DOI: 10.1183/13993003.congress-2016.PA4903
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