Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Subscriptions

TNFAIP3 (A20) expression is elevated in the sputum of severe asthmatics

Stelios Pavlidis, Fan Chung, Anthony Rowe, Ioannis Pandis, Ratko Djukanovic, Peter Sterk, Yike Guo, Ian Adcock
European Respiratory Journal 2016 48: PA4900; DOI: 10.1183/13993003.congress-2016.PA4900
Stelios Pavlidis
1Airways Disease Section, Imperial College London, London, United Kingdom
2Data Science Institute - Department of Computing, Imperial College London, London, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Fan Chung
1Airways Disease Section, Imperial College London, London, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anthony Rowe
3Janssen Research & Development, Johnson and Johnson, High Wycombe, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ioannis Pandis
2Data Science Institute - Department of Computing, Imperial College London, London, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ratko Djukanovic
4Southampton NIHR Respiratory Biomedical Research Unit, Southampton University, Southampton, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter Sterk
5Faculty of Medicine, University of Amsterdam, Amsterdam, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yike Guo
2Data Science Institute - Department of Computing, Imperial College London, London, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ian Adcock
1Airways Disease Section, Imperial College London, London, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
Loading

Abstract

Background: TNFAIP3 is a ubiquitin-modifying enzyme that attenuates NF-kB activation and is reported to be suppressed in epithelial cultures of severe asthma patients (Schuijs MJ et al., Science 2015).

Aims & Objectives: To investigate TNFAIP3 gene expression in bronchial brushings and sputum cells in subjects from the U-BIOPRED consortium.

Methods: We used gene expression analysis to study TNFAIP3 expression in bronchial biopsies (n=108), bronchial brushings (n=147) and sputum (n=120), from healthy controls (HC), mild moderate asthmatics (MMA) and severe asthmatics who were smokers (SAsm) or non-smokers (SAn) in the U-BIOPRED cohort.

Results: There was no change in TNFAIP3 expression in bronchial biopsies or bronchial brushings between any of the subject groups. In contrast TNFAIP3 expression was significantly increased in sputum cells from SA patients, 1.6-fold between SAn and HC and 2.3-fold between SAn and MMA. Differences were greater when subjects were grouped according to sputum granulocytes. Neutrophilic and mixed granulocyte asthmatics expressed the highest levels of TNFAIP3 with a 3.8-fold increase seen between neutrophilic and paucigranulocytic asthmatics (FDR<10-6).

Conclusion: TNFAIP3 expression is not reduced in bronchial biopsies in asthma but is markedly elevated in SAn and particularly in those with neutrophilic asthma. Further analysis of ubiquitin and de-ubiquitinating enzymes in severe asthma is required.

EU-IMI Funded

Figure
  • Download figure
  • Open in new tab
  • Download powerpoint

  • Asthma - mechanism
  • Biomarkers
  • Bronchoscopy
  • Copyright ©the authors 2016
Previous
Back to top
Vol 48 Issue suppl 60 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
TNFAIP3 (A20) expression is elevated in the sputum of severe asthmatics
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
TNFAIP3 (A20) expression is elevated in the sputum of severe asthmatics
Stelios Pavlidis, Fan Chung, Anthony Rowe, Ioannis Pandis, Ratko Djukanovic, Peter Sterk, Yike Guo, Ian Adcock
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4900; DOI: 10.1183/13993003.congress-2016.PA4900

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
TNFAIP3 (A20) expression is elevated in the sputum of severe asthmatics
Stelios Pavlidis, Fan Chung, Anthony Rowe, Ioannis Pandis, Ratko Djukanovic, Peter Sterk, Yike Guo, Ian Adcock
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4900; DOI: 10.1183/13993003.congress-2016.PA4900
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Figures & Data
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • TRPM3: A regulator of airway sensory nerves and respiratory reflexes
  • Anti-inflammatory activity of the bradykinin B1R antagonist in a model of LPS-induced lung inflammation in cynomolgus monkey
  • Prostacyclin IP receptor activation blocks hyperosmolar-induced bronchoconstriction in isolated human small airways
Show more 5.1 Airway Pharmacology and Treatment

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society