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Cytokine profile in bronchoalveolar lavage fluid of fibrotic idiopathic intersticial pneumonias compared to fibrotic intersticial pneumonias in connective tissue diseases

Martina Kolbeková, Martina Šterclová, Magdalena Smetáková, Peter Paluch, Jan Anton, Jelena Skibová, Martina Vašáková
European Respiratory Journal 2016 48: PA4884; DOI: 10.1183/13993003.congress-2016.PA4884
Martina Kolbeková
1Department of Respiratory Medicine of the 1st Medical School of Charles University, Thomayer Hospital Prague, Prague, Czech Republic
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Martina Šterclová
1Department of Respiratory Medicine of the 1st Medical School of Charles University, Thomayer Hospital Prague, Prague, Czech Republic
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Magdalena Smetáková
1Department of Respiratory Medicine of the 1st Medical School of Charles University, Thomayer Hospital Prague, Prague, Czech Republic
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Peter Paluch
1Department of Respiratory Medicine of the 1st Medical School of Charles University, Thomayer Hospital Prague, Prague, Czech Republic
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Jan Anton
1Department of Respiratory Medicine of the 1st Medical School of Charles University, Thomayer Hospital Prague, Prague, Czech Republic
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Jelena Skibová
2Department of Pathology, Thomayer Hospital Prague, Prague, Czech Republic
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Martina Vašáková
1Department of Respiratory Medicine of the 1st Medical School of Charles University, Thomayer Hospital Prague, Prague, Czech Republic
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Abstract

Objectives: Fibroproliferative type of healing of lung tissue can be found in idiopathic intersticial pneumonias (fIIPs),but also in interstitial pneumonias accompanying connective tissue diseases (fIP-CTDs).

Aim: To prove, if there is a difference between pathogenetic pathways of fIIPs and fIP-CTDs by comparing proteinaceous parameters in bronchoalveolar lavage fluid (BALF).

Material and methods: We compared 2 groups:22 patients with fIIP (5women/17 men, mean age 68.3±5.4,17smokers/5non-smokers), 22 patients with fIP-CTDs (14 women/8 men, mean age 61.82±13.0,10smokers/12non-smokers). In fIIPs 4 patients had NSIP and 18 IPF. In fIP-CTDs 12 patients had NSIP,9 UIP and 1 AIP pattern. All patients underwent bronchoalveolar lavage at the time of diagnosis. BALF concentrations of matrix metalloproteinase-7(MMP7), interleukin-4 receptor(IL4-R), proteinase activated receptor 2(PAR-2), B-cell activating factor (BAFF) and tumor necrosis factor-α(TNFα) were measured by ELISA (Cloud nad Clone Corp.,USA). We used two group t-test and Chi-square test in frequency tables to state statistically significant data.

Results: Patiens with fIPs-CTDs were significantly younger (p<0.05), women (p<0.01) and also smokers prevailed (p<0.05). We found significantly higher concentrations of TNF-α (3.04±2.19 vs. 1,49±0,78 pg/ml, p<0.01), lower concentrations of MMP7 (2.07±1.45 vs. 3,26±2,09 pg/ml, p<0.05) in BALF in fIP-CTDs.

Conclusion: Higher levels of TNF-α in BALF in fIP-CTDs might reflect inflammatory background of CTDs. Higher levels of MMP-7 in BALF in fIIPs can represent accented fibroproliferative healing in fIIPs compared to fIP-CTDs.

  • Interstitial lung disease (connective tissue disease)
  • Biomarkers
  • Bronchoalveolar lavage
  • Copyright ©the authors 2016
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Cytokine profile in bronchoalveolar lavage fluid of fibrotic idiopathic intersticial pneumonias compared to fibrotic intersticial pneumonias in connective tissue diseases
Martina Kolbeková, Martina Šterclová, Magdalena Smetáková, Peter Paluch, Jan Anton, Jelena Skibová, Martina Vašáková
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4884; DOI: 10.1183/13993003.congress-2016.PA4884

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Cytokine profile in bronchoalveolar lavage fluid of fibrotic idiopathic intersticial pneumonias compared to fibrotic intersticial pneumonias in connective tissue diseases
Martina Kolbeková, Martina Šterclová, Magdalena Smetáková, Peter Paluch, Jan Anton, Jelena Skibová, Martina Vašáková
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4884; DOI: 10.1183/13993003.congress-2016.PA4884
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