Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Idiopathic non-specific interstitial pneumonia (iNSIP): do the patients develop connective tissue disease (CTD) during follow-up?

Janne Møller, Alan Altraja, Tone Sjåheim, Line Bille Madsen, Finn Rasmussen, Elisabeth Bendstrup
European Respiratory Journal 2016 48: PA4876; DOI: 10.1183/13993003.congress-2016.PA4876
Janne Møller
1Department of Respiratory Diseases and Allergology, Aarhus University Hospital, Aarhus, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alan Altraja
2Department of Respiratory Diseases, University of Tartu, Tallinn, Estonia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tone Sjåheim
3Department of Respiratory Diseases, Oslo University Hospital, Oslo, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Line Bille Madsen
4Department of Pathology, Aarhus University Hospital, Aarhus, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Finn Rasmussen
5Department of Radiology, Aarhus University Hospital, Aarhus, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elisabeth Bendstrup
1Department of Respiratory Diseases and Allergology, Aarhus University Hospital, Aarhus, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Background: INSIP is a rare interstitial lung disease and diagnosis by definition, demands a multidisciplinary team (MDT) discussion. It has been suggested that iNSIP might be associated with an autoimmune background that later reveals itself as an autoimmune disease.

Aims: Using the MDT approach, we aimed at establishing a retrospective, multinational cohort of a larger number of iNSIP patients to characterize the clinical properties at baseline and development of CTD.

A pilot study was done to test the feasibility of the above. We report here the incidence of CTD during the follow-up.

Methods: Investigators from three expert centers (Denmark, Estonia and Norway) met and discussed 31 cases of biopsy-proven iNSIP at an international MDT. Cases were previously diagnosed at a national level between 2004 and 2014. Based on all available data, the diagnosis of iNSIP was re-evaluated and a consensus diagnosis was made. Cases incompatible with iNSIP were excluded. Relevant data were registered comprising any development of CTD.

Results: Twenty-three patients were included. Ten (43.5%) had extrapulmonary symptoms. Serology was positive in 6 patients (26.1%) of whom, 4 had extrapulmonary symptoms.

The mean follow-up time was 57 months. None of the patients developed any CTD that fulfilled the classical rheumatologic criteria during the observation period. Four patients (17.4%) fulfilled the criteria for interstitial pneumonia with autoimmune features (IPAF).

Conclusion: In this iNSIP cohort no patients developed CTD during the follow-up making the term “idiopathic” more confident and not supportive of the thesis of autoimmune pathogenesis.

  • Interstitial lung disease
  • Interstitial lung disease (connective tissue disease)
  • Epidemiology
  • Copyright ©the authors 2016
Previous
Back to top
Vol 48 Issue suppl 60 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Idiopathic non-specific interstitial pneumonia (iNSIP): do the patients develop connective tissue disease (CTD) during follow-up?
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Idiopathic non-specific interstitial pneumonia (iNSIP): do the patients develop connective tissue disease (CTD) during follow-up?
Janne Møller, Alan Altraja, Tone Sjåheim, Line Bille Madsen, Finn Rasmussen, Elisabeth Bendstrup
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4876; DOI: 10.1183/13993003.congress-2016.PA4876

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Idiopathic non-specific interstitial pneumonia (iNSIP): do the patients develop connective tissue disease (CTD) during follow-up?
Janne Møller, Alan Altraja, Tone Sjåheim, Line Bille Madsen, Finn Rasmussen, Elisabeth Bendstrup
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4876; DOI: 10.1183/13993003.congress-2016.PA4876
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Acute hyperoxic challenge improves haemodynamics & Pulmonary vascular stiffness in interstitial lung disease-associated pulmonary hypertension
  • Usual interstitial pneumonia preceding rheumatoid arthritis: Clinical, imaging, and histopathologic features
  • Serum surfactant protein D is a potential biomarker of lung damage in systemic sclerosis
Show more 1.5 Diffuse Parenchymal Lung Disease

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2022 by the European Respiratory Society