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Screening for intracerebral metastasis in radically treated non-small cell lung cancer patients

Wang Yng Lim, Sam Roberts, Claire Exley, Llinos Jones
European Respiratory Journal 2016 48: PA4852; DOI: 10.1183/13993003.congress-2016.PA4852
Wang Yng Lim
1Respiratory Medicine, Mid Yorkshire Hospitals NHS trust, Wakefield, United Kingdom
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Sam Roberts
1Respiratory Medicine, Mid Yorkshire Hospitals NHS trust, Wakefield, United Kingdom
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Claire Exley
2Radiology, Mid Yorkshire Hospitals NHS trust, Wakefield, United Kingdom
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Llinos Jones
1Respiratory Medicine, Mid Yorkshire Hospitals NHS trust, Wakefield, United Kingdom
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Abstract

Introduction Whilst recurrence is a well recognised phenomenon, the optimal protocol for surveillance after surgical treatment of non-small cell lung cancer (NSCLC) remains unclear. Early identification of intracerebral disease can improve morbidity and mortality (Linskey ME et al. J Neurooncol 2010; 96:45-68). In February 2015 CT head was added to routine CT chest/abdomen at 3, 12 and 24 months after surgery for all resected NSCLC patients at our trust.

Methods We prospectively reviewed all CT scans from February 2015 for patients undergoing radical surgery for NSCLC. We report data to January 2016.

Results 61 patients were identified. All patients had a baseline CT head prior to surgery showing no evidence of metastasis. There were 3 cases (5%) of intracerebral recurrence identified on CT surveillance. 2 patients were asymptomatic with intracerebral metastases amenable to stereotactic ablative radiotherapy (SABR). 1 patient was symptomatic and unfit for further treatment. 2 patients had R0 disease. Financial cost of adding CT head is minimal. There is only marginal increase in radiation dose (extra 1.8mSv).

Conclusion The introduction of CT head as part of surveillance of radically treatment non-small cell lung cancer patients has led to early identification of intracerebral recurrence amenable to treatment with SABR. The availability of SABR has led to longer patient survival in patients with solid brain metastases.

  • Imaging
  • Lung cancer / Oncology
  • Monitoring
  • Copyright ©the authors 2016
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Screening for intracerebral metastasis in radically treated non-small cell lung cancer patients
Wang Yng Lim, Sam Roberts, Claire Exley, Llinos Jones
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4852; DOI: 10.1183/13993003.congress-2016.PA4852

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Screening for intracerebral metastasis in radically treated non-small cell lung cancer patients
Wang Yng Lim, Sam Roberts, Claire Exley, Llinos Jones
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4852; DOI: 10.1183/13993003.congress-2016.PA4852
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