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DP2/CRTh2 is expressed by ASM cells in asthma and its inhibition suppresses ASM migration

Ruth Saunders, Michael Biddle, Adam Wright, Latifa Chachi, Amanda Sutcliffe, Rachid Berair, Christopher Brightling
European Respiratory Journal 2016 48: PA4653; DOI: 10.1183/13993003.congress-2016.PA4653
Ruth Saunders
1Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
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Michael Biddle
1Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
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Adam Wright
1Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
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Latifa Chachi
1Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
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Amanda Sutcliffe
1Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
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Rachid Berair
1Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
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Christopher Brightling
1Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
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Tables

  • TABLE 1
    Vehicle control10nM CAY10471
    Wound healing (cells moved into wound after 24h)92±378±4∗
    F-actin content (phalloidin gMFI % vehicle control)10092±2∗
    α-SMA expression (gMFI α-SMA/isotype control antibody)44±748±6
    Cell size (forward scatter, % vehicle control)10099±0.2
    Cell granularity (side scatter, % vehicle control)10099±1
    • ∗p<0.05 vs vehicle control, n=4, mean±sem.

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DP2/CRTh2 is expressed by ASM cells in asthma and its inhibition suppresses ASM migration
Ruth Saunders, Michael Biddle, Adam Wright, Latifa Chachi, Amanda Sutcliffe, Rachid Berair, Christopher Brightling
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4653; DOI: 10.1183/13993003.congress-2016.PA4653

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DP2/CRTh2 is expressed by ASM cells in asthma and its inhibition suppresses ASM migration
Ruth Saunders, Michael Biddle, Adam Wright, Latifa Chachi, Amanda Sutcliffe, Rachid Berair, Christopher Brightling
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4653; DOI: 10.1183/13993003.congress-2016.PA4653
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More in this TOC Section

  • T lymphocytes in cigarette-smoke induced-emphysema and bronchial remodelling
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  • Inhibition of asthma-related immunological responses in mast cells and Th2 cell lines by cultured epithelial cell lines
Show more 3.2 Airway Cell Biology and Immunopathology

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