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Impact of diabetes mellitus on survival and hospitalization after lung transplantation

Marianne Riou, Philippe Baltzinger, Michele Porzio, Tristan Degot, Sandrine Hirschi, Nicola Santelmo, Pierre-Emmanuel Falcoz, Gilbert Massard, Laurence Kessler, Romain Kessler
European Respiratory Journal 2016 48: PA4645; DOI: 10.1183/13993003.congress-2016.PA4645
Marianne Riou
1Groupe de Transplantation Pulmonaire, Nouvel Hôpital Civil, CHU Strasbourg, Strasbourg, France
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Philippe Baltzinger
2Service D'endocrinologie - Diabète et Maladies Métaboliques, Médicale B, Hôpital Civil, CHU Strasbourg, Strasbourg, France
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Michele Porzio
1Groupe de Transplantation Pulmonaire, Nouvel Hôpital Civil, CHU Strasbourg, Strasbourg, France
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Tristan Degot
1Groupe de Transplantation Pulmonaire, Nouvel Hôpital Civil, CHU Strasbourg, Strasbourg, France
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Sandrine Hirschi
1Groupe de Transplantation Pulmonaire, Nouvel Hôpital Civil, CHU Strasbourg, Strasbourg, France
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Nicola Santelmo
1Groupe de Transplantation Pulmonaire, Nouvel Hôpital Civil, CHU Strasbourg, Strasbourg, France
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Pierre-Emmanuel Falcoz
1Groupe de Transplantation Pulmonaire, Nouvel Hôpital Civil, CHU Strasbourg, Strasbourg, France
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Gilbert Massard
1Groupe de Transplantation Pulmonaire, Nouvel Hôpital Civil, CHU Strasbourg, Strasbourg, France
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Laurence Kessler
2Service D'endocrinologie - Diabète et Maladies Métaboliques, Médicale B, Hôpital Civil, CHU Strasbourg, Strasbourg, France
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Romain Kessler
1Groupe de Transplantation Pulmonaire, Nouvel Hôpital Civil, CHU Strasbourg, Strasbourg, France
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Abstract

Introduction: Diabetes mellitus (DM) is a risk factor for mortality and morbidity after solid organ transplantation (kidney, liver). The objective of our study was to determine the effect of DM on survival and unscheduled hospitalizations after lung transplantation.

Patients and methods: We included retrospectively 256 patients who received a single or double lung transplantation at Strasbourg University Hospital between 2004 and 2014. The indications for lung transplantation were: COPD (43,4%), cystic fibrosis (21,9%), and pulmonary fibrosis (19,2%). 80% were bilateral transplantations. We grouped the patients into 3 relevant categories of DM: pre- and post-transplant DM, new onset (>3 months) diabetes after transplantation (NODAT) and the control group of non-diabetic patients.

Résults: 78 patients had pre&post DM and 48 patients developed NODAT. Cystic fibrosis patients had the highest prevalence (50%) of pre&post DM and NODAT.

We found a significant difference for unscheduled hospital stays between the 3 groups: the duration of hospital stays [mean±SD] was 86±121 days/year for pre&post DM patients, 50±67 days/year for NODAT, and 78±120 days/year for non-diabetic patients (p=0,032).

We observed a worse survival after transplantation in pre&post DM compared to patients without pre-transplant DM (3-months median conditional survival: 6.3 ± 1.6 vs 8.8 ± 0.7 years, p = 0.016). There was no difference in survival for NODAT patients compared to non-diabetic patients (3 months conditional median survival: 10.5 ± 2 years versus 8.4 ± 1.6, NS).

Conclusion: DM might have an impact on survival after lung transplantation. An organized and cooperative management of pre&post DM and NODAT seems warranted.

  • Transplantation
  • Comorbidities
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Impact of diabetes mellitus on survival and hospitalization after lung transplantation
Marianne Riou, Philippe Baltzinger, Michele Porzio, Tristan Degot, Sandrine Hirschi, Nicola Santelmo, Pierre-Emmanuel Falcoz, Gilbert Massard, Laurence Kessler, Romain Kessler
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4645; DOI: 10.1183/13993003.congress-2016.PA4645

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Impact of diabetes mellitus on survival and hospitalization after lung transplantation
Marianne Riou, Philippe Baltzinger, Michele Porzio, Tristan Degot, Sandrine Hirschi, Nicola Santelmo, Pierre-Emmanuel Falcoz, Gilbert Massard, Laurence Kessler, Romain Kessler
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4645; DOI: 10.1183/13993003.congress-2016.PA4645
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More in this TOC Section

  • KL-6 in serum as a biomarker for differentiation of chronic allograft dysfuntion in lung transplant. Preliminary results
  • Uncontrolled non-heart-beating donors vs. brain dead donors in lung transplantation: Comparison of early and late results
Show more 8.2 Transplantation

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