Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Long-term survivalaccording to Czech clinical phenotypes of COPD- Czech multicentre research database of severe COPD

Marek Plutinsky, Barbora Novotna, Patrice Popelkova, Zatloukal Jaromir, Vladimir Koblizek, Karek Hejduk, Michal Svoboda
European Respiratory Journal 2016 48: PA4622; DOI: 10.1183/13993003.congress-2016.PA4622
Marek Plutinsky
1Department of Pulmonology, University Hospital, Masaryk University, Brno, Czech Republic
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Barbora Novotna
2Department of Pulmonology, University Hospital, Hradec Kralove, Czech Republic
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Patrice Popelkova
3Department of Pulmonology, University Hospital, Ostrava, Czech Republic
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zatloukal Jaromir
4Department of Pulmonology, University Hospital, Olomouc, Czech Republic
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vladimir Koblizek
5Department of Pulmonology, University Hospital, Hradec Kralove, Czech Republic
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karek Hejduk
6Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michal Svoboda
7Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Background: COPD is a heterogeneous condition with several clinical variants. The Czech Pneumological and Phthisiological Society defines 6 clinically relevant phenotypes: frequent exacerbator (FE), COPD-asthma overlap syndrome (ACOS), COPD-bronchiectasis overlap syndrome (BCOS), emphysematic phenotype (E), bronchitic phenotype (B), and pulmonary cachexia phenotype (CA).

Methods: The Czech Multicentre Research Database of COPD (NCT01923051) is a multicentre, observational, and prospective study of consecutive patients with severe COPD (post-BT FEV1≤60%). The primary objective is to assess the all-cause mortality, as well as the assessment of prognostic COPD indexes, identication of clinical phenotypes, lung function and respiratory symptoms.

Results: 647 severe COPD subjects were enrolled until Jan 2016. 637 of them were eligible for two-year analysis (67 ± 13yrs, post-BD FEV1 43.0±17.7%). On the whole, 388 (60.9%) were B, 254 (39.9%) were E, 193 (69.7%) were FE, 107 (16.8%) were BCOS, 94 (14.6%) were CA and 18 (2.8%) were ACOS subjects. 59 patients (16.1%) have died. We have found a significantly higher amount of deaths in the CA group (23, i.e. 30.7%, p < 0.001) and the FE group (24, i.e. 15.1%, p = 0.035). On the contrary there was no death in the ACOS group (0%). We confirmed a good correlation between mortality and the ADO index (p < 0.003) and the Yokohama score (YCS) (p = 0.025).

Conclusion: Two clinical phenotypes, CA and FE, are associated with a significantly higher risk of death. ADO index and YCS appear to be suitable prognostic tools.

  • COPD - exacerbations
  • Longitudinal study
  • Public health
  • Copyright ©the authors 2016
Previous
Back to top
Vol 48 Issue suppl 60 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Long-term survivalaccording to Czech clinical phenotypes of COPD- Czech multicentre research database of severe COPD
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Long-term survivalaccording to Czech clinical phenotypes of COPD- Czech multicentre research database of severe COPD
Marek Plutinsky, Barbora Novotna, Patrice Popelkova, Zatloukal Jaromir, Vladimir Koblizek, Karek Hejduk, Michal Svoboda
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4622; DOI: 10.1183/13993003.congress-2016.PA4622

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Long-term survivalaccording to Czech clinical phenotypes of COPD- Czech multicentre research database of severe COPD
Marek Plutinsky, Barbora Novotna, Patrice Popelkova, Zatloukal Jaromir, Vladimir Koblizek, Karek Hejduk, Michal Svoboda
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4622; DOI: 10.1183/13993003.congress-2016.PA4622
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Assessment of lung volumes and capacities in bronchodilator reversibility changes of hyperinflation of COPD
  • Blood eosinophils and outcomes in COPD
Show more 1.12 Clinical Problems - COPD

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society