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Association between adipokines, inflammatory markers and systemic manifestations in chronic obstructive pulmonary disease (COPD) patients

Carolina Mesquita, Robson Prudente, Laura Caram, Caroline Knaut, Estefânia Franco, Duelene Ludimila Nogueira, Liana Coelho, Irma Godoy, Suzana Minamoto
European Respiratory Journal 2016 48: PA4615; DOI: 10.1183/13993003.congress-2016.PA4615
Carolina Mesquita
1Department of Internal Medicine, Pneumology Area, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu Campus, Botucatu, São PauloBrazil
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Robson Prudente
1Department of Internal Medicine, Pneumology Area, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu Campus, Botucatu, São PauloBrazil
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Laura Caram
1Department of Internal Medicine, Pneumology Area, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu Campus, Botucatu, São PauloBrazil
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Caroline Knaut
1Department of Internal Medicine, Pneumology Area, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu Campus, Botucatu, São PauloBrazil
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Estefânia Franco
1Department of Internal Medicine, Pneumology Area, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu Campus, Botucatu, São PauloBrazil
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Duelene Ludimila Nogueira
1Department of Internal Medicine, Pneumology Area, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu Campus, Botucatu, São PauloBrazil
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Liana Coelho
1Department of Internal Medicine, Pneumology Area, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu Campus, Botucatu, São PauloBrazil
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Irma Godoy
1Department of Internal Medicine, Pneumology Area, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu Campus, Botucatu, São PauloBrazil
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Suzana Minamoto
1Department of Internal Medicine, Pneumology Area, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu Campus, Botucatu, São PauloBrazil
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Abstract

Introduction: Recent studies have shown that adipose tissue can contributes to increase systemic inflammation and can be associated to systemic manifestations in COPD.

Objectives: The aim of this study was to evaluate adipokines and systemic inflammation COPD patients.

Methods: We evaluated 59 mild to very severe COPD patients according to GOLD. Clinical and laboratory evaluation, pre-and post-bronchodilator spirometry, pulse oximetry, body mass index - BMI, fat-free mass - FFM and FFF index, six minute walk distance (6MWD), health status (St. George Respiratory Disease Questionnaire SGRQ and Hospital Anxiety and Depression Scale HAD) were evaluated. Concentrations of interleukin 6 (IL-6), C-reactive protein (CRP), adiponectin and leptin were measured in serum.

Results: 13.6% of patients were mild COPD, 45.7% moderate, 25.4% severe and 15.3% very severe. When patients were categorized according to BODE index, adipokines and others systemic inflammation did not differ between groups. However, when categorized according to GOLD, patients with moderate [0.27 (0.20-0.29) vs 0.53 (0.43-0.61) p=0,002] and severe [0.27 (0.20-0.29) vs 0.47 (0.38-0.61) p=0,018] COPD showed higher leptin concentrations than mild COPD. We identified negative correlation of leptin with age (R= -0.41, p=0.001), and positive association of leptin with BMI (R= 0.600, p= <0.001) and CRP (R= 0.322, p=0.02). 6MWD showed negative correlation with CRP (R= -0.341, p=0.03) and adiponectin (R= -0303, p=0.04).

Conclusion: Increased adipokines and inflammatory markers were correlated with body composition and exercise capacity in COPD patients.

  • COPD - diagnosis
  • Inflammation
  • Biomarkers
  • Copyright ©the authors 2016
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Association between adipokines, inflammatory markers and systemic manifestations in chronic obstructive pulmonary disease (COPD) patients
Carolina Mesquita, Robson Prudente, Laura Caram, Caroline Knaut, Estefânia Franco, Duelene Ludimila Nogueira, Liana Coelho, Irma Godoy, Suzana Minamoto
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4615; DOI: 10.1183/13993003.congress-2016.PA4615

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Association between adipokines, inflammatory markers and systemic manifestations in chronic obstructive pulmonary disease (COPD) patients
Carolina Mesquita, Robson Prudente, Laura Caram, Caroline Knaut, Estefânia Franco, Duelene Ludimila Nogueira, Liana Coelho, Irma Godoy, Suzana Minamoto
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4615; DOI: 10.1183/13993003.congress-2016.PA4615
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