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Relationship between blood eosinophil count (Eos), clinical characteristics and mortality of patients with COPD

Maeva Zysman, Pierre Regis Burgel, Jean Louis Paillasseur, Pascal Chanez, Denis Caillaud, Roger Escamilla, Isabelle Court Fortune, Pascal Nesme Meyer, Graziella Brinchault Rabin, Gaetan Deslee, Thierry Perez, Christophe Pinet, Nicolas Roche
European Respiratory Journal 2016 48: PA4614; DOI: 10.1183/13993003.congress-2016.PA4614
Maeva Zysman
1Pulmonary Dpt, CHU Vandoeuvre, EA Ingres, Nancy, France
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Pierre Regis Burgel
2Respiratory and Intensive Care Medicine, Cochin Hospital, AP-HP and Paris Descartes University, Sorbonne Paris Cité, Paris, France
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Jean Louis Paillasseur
3Pulmonary Dpt, EFFI-STAT, Paris, France
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Pascal Chanez
4Pulmonary Dpt, APHM, INSERM U1077, CNRS UMR 7733 Aix Marseille Université, Marseille, France
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Denis Caillaud
5Pulmonary Dpt, Gabriel Montpied University Hospital, Clermont Ferrand, France
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Roger Escamilla
6Pulmonary Dpt, Respiratory and Intensive Care Medicine, Toulouse, France
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Isabelle Court Fortune
7Pulmonary Dpt, University Hospital, Saint Etienne, France
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Pascal Nesme Meyer
8Pulmonary Dpt, La Croix Rousse University Hospital, Lyon, France
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Graziella Brinchault Rabin
9Pulmonary Dpt, CHU Pontchaillou, Rennes, France
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Gaetan Deslee
10Pulmonary Dpt, Maison Blanche University Hospital, INSERM U903, Reims, France
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Thierry Perez
11Pulmonary Dpt, Albert Calmette University Hospital, Lille, France
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Christophe Pinet
12Pulmonary Dpt, Polyclinique Les Fleurs, Ollioules, France
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Nicolas Roche
134Respiratory and Intensive Care Medicine, Cochin Hospital, AP-HP and Paris Descartes University, Sorbonne Paris Cité, Paris, France
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Abstract

Background: Several studies suggest that, in patients with COPD, Eos is associated with (i) exacerbation frequency and (ii) the effect of inhaled corticosteroid for exacerbation prevention.

Aim: To determine whether Eos defines patients' groups exhibiting attributes of COPD clinical phenotypes, we compared the clinical features and mortality rate between COPD patients with ≥2% (Eos+) and <2% (Eos-) blood eosinophils in the Initiatives BPCO French cohort.

Methods: The following data were collected at inclusion: medical and smoking history, occupational exposures, dyspnea, cough and sputum production, exacerbations in the previous year, history of allergy and asthma, nasal symptoms, BMI, SGRQ score, post-bronchodilator spirometry and plethysmography, comorbidities, CRP and medications. Three-year survival was available for all patients. BOD and ADO scores were calculated.

Results: Eos was available in 458 patients (mean age: 62 years, 72% male, mean FEV1: 51%), including 235 Eos+ patients (49%). No difference between Eos+ and Eos- groups was observed in univariate analyses except for diabetes (17% in Eos-, 8% in Eos+, p=0.02) and SGRQ score (mean, 48 units in Eos -, 40 units in Eos+, p=0.007). In particular, there was no difference in term of exacerbations rate (mean, 1.6/patient/year) or history of asthma (15% of the population). Three-year mortality rate was 17% in Eos- vs 13% in Eos+ (NS).

Conclusion: Apart from differences in health-related quality of life and frequency of diabetes (which warrant further investigation), Eos+ COPD patients exhibit no specific clinical characteristic, especially regarding symptoms, lung function, exacerbations and prognosis.

  • COPD - management
  • Longitudinal study
  • Comorbidities
  • Copyright ©the authors 2016
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Relationship between blood eosinophil count (Eos), clinical characteristics and mortality of patients with COPD
Maeva Zysman, Pierre Regis Burgel, Jean Louis Paillasseur, Pascal Chanez, Denis Caillaud, Roger Escamilla, Isabelle Court Fortune, Pascal Nesme Meyer, Graziella Brinchault Rabin, Gaetan Deslee, Thierry Perez, Christophe Pinet, Nicolas Roche
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4614; DOI: 10.1183/13993003.congress-2016.PA4614

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Relationship between blood eosinophil count (Eos), clinical characteristics and mortality of patients with COPD
Maeva Zysman, Pierre Regis Burgel, Jean Louis Paillasseur, Pascal Chanez, Denis Caillaud, Roger Escamilla, Isabelle Court Fortune, Pascal Nesme Meyer, Graziella Brinchault Rabin, Gaetan Deslee, Thierry Perez, Christophe Pinet, Nicolas Roche
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4614; DOI: 10.1183/13993003.congress-2016.PA4614
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