Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions

Pattern of diffusion disturbance in patients with interstitial lung diseases (ILDs)

Marina Yu Kameneva, Vasiliy Trofimov, Artem Tishkov, Alexandra Speranskaya, Ivetta Dvorakovskaya, Olga Baranova
European Respiratory Journal 2016 48: PA4407; DOI: 10.1183/13993003.congress-2016.PA4407
Marina Yu Kameneva
1Hospital Therapy, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vasiliy Trofimov
1Hospital Therapy, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Artem Tishkov
2Physics, Mathematics and Informatics, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexandra Speranskaya
3Radiology and Radiation Therapy, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ivetta Dvorakovskaya
4Institute of Pulmonology, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Olga Baranova
5Institute of Interstitial and Orphan Diseases, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Aim: to classify diffusion disturbances in patients with ILDs in four patterns, using body plethysmography and single-breath carbon monoxide diffusing capacity (DLCO): the pattern of alveolar-capillary membrane damage (AMD), the pattern of air trapping (AT), the pattern of gas-exchanging surface reduction (GSR) and the pattern of mixed gas exchange abnormalities (MA).

Results: the parameters of DLCO and body plethysmography were analyzed in 336 patients with ILDs: 110 male (age M 45.3 SD 15.3 yr) and 226 female (age M 51.3 SD 12.3 yr). The alveolar volume (VA) is informative for the characteristic of gas-exchanging surface. Non-communicating gas volume (ΔTLC=TLCpleth–TLCHe) is informative for air trapping assessment. The AMD pattern (n=96) is defined as decreased DLCO, normal VA and ΔTLC. In this case membrane is damaged, but surface is still not reduced. Patients with AT pattern (n=75) have decreased DLCO, normal VA and increased ΔTLC. The GSR pattern (n=119) is defined as decreased DLCO, decreased VA and normal ΔTLC. Patients with MA pattern (n=46) have decreased DLCO, decreased VA and increased ΔTLC. Ventilation disorders and diffusion disturbance patterns correlate, but not determine each other. In patients with restrictive disorder GSR pattern was prevailed (67%). Almost half of the cases with obstructive disorder had AT pattern (49%). However, in normal, obstructive, restrictive and mixed ventilation disorder groups, all patterns of diffusion disturbance were detected.

Conclusions: Recognition of four patterns of diffusion disturbance in ILDs patients provides significant details to ventilatory disorder study and helps to determine the individual characteristics of the disease course.

  • Lung function testing
  • Interstitial lung disease
  • Gas exchange
  • Copyright ©the authors 2016
Previous
Back to top
Vol 48 Issue suppl 60 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Pattern of diffusion disturbance in patients with interstitial lung diseases (ILDs)
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Pattern of diffusion disturbance in patients with interstitial lung diseases (ILDs)
Marina Yu Kameneva, Vasiliy Trofimov, Artem Tishkov, Alexandra Speranskaya, Ivetta Dvorakovskaya, Olga Baranova
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4407; DOI: 10.1183/13993003.congress-2016.PA4407

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Pattern of diffusion disturbance in patients with interstitial lung diseases (ILDs)
Marina Yu Kameneva, Vasiliy Trofimov, Artem Tishkov, Alexandra Speranskaya, Ivetta Dvorakovskaya, Olga Baranova
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4407; DOI: 10.1183/13993003.congress-2016.PA4407
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • An alternative approach to define reference values of whole-body plethysmography in infants, children and adults
  • Airway model reconstructed from CT images
  • Role of sampling flow in the sidestream capnographic shape factors
Show more 9.1 Respiratory Function Technologists/Scientists

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2021 by the European Respiratory Society