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Response to bronchodilators in school children with asthma and normal FEV1

Aleksandar Kamenov, Svetlana Kamenov, Milan Tosic, Ivana Vidanovic, Borislav Kamenov
European Respiratory Journal 2016 48: PA4393; DOI: 10.1183/13993003.congress-2016.PA4393
Aleksandar Kamenov
2Clinic of Pediatry, Clinical Center Nis, Nis, Republic of Serbia
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Svetlana Kamenov
1Department of Pulmology, Health Center Nis, Nis, Republic of Serbia
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Milan Tosic
1Department of Pulmology, Health Center Nis, Nis, Republic of Serbia
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Ivana Vidanovic
2Clinic of Pediatry, Clinical Center Nis, Nis, Republic of Serbia
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Borislav Kamenov
2Clinic of Pediatry, Clinical Center Nis, Nis, Republic of Serbia
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Abstract

Background: Asthma is a chronic inflammatory disorder of the airways, associated with variable airflow obstruction that is at least partly reversible, either spontaneously or with treatment. When assessing asthma, FEV1 is often the only functional parameter considered.

Aim: To evaluate if there is a positive response to bronchodilators in school children with asthma and normal FEV1. To correlate this results with clinical parameters of disease.

Method: 190 asthmatic children with normal FEV1 were included and submitted to lung function testing with bronchodilation. We evaluated bronchodilator response (BDR) and questioned them about several clinical aspects (daily medication, rescue medication, asthma exacerbations, nocturnal symptoms and exercise-induced symptoms), in the past 3 months. We considered a normal FEV1 when it was 80% of the predicted value (PV) and a positive BDR when FEV1 increased for at least 12% after administration of bronchodilators.

Results: 85 male and 105 female patients; 75 were atopic; 25 patients had intermittent asthma, 48 mild persistent and 42 moderate persistent asthma. There was a positive BDR in 52 patients (I group). In this group, 15 patients referred nocturnal and/or exercise-induced symptoms vs. 138 from those with a negative BDR (II group). Regarding daily medication, 21/52 patients with positive BDR and 50/138 from those with negative BDR were on inhaled corticosteroids.

Conclusion: In this study 27.3% of asthmatic children had a positive BDR, although presenting normal FEV1. A positive BDR correlated with clinical parameters, mainly with recent asthma exacerbations.

  • Asthma - management
  • Spirometry
  • Exacerbation
  • Copyright ©the authors 2016
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Response to bronchodilators in school children with asthma and normal FEV1
Aleksandar Kamenov, Svetlana Kamenov, Milan Tosic, Ivana Vidanovic, Borislav Kamenov
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4393; DOI: 10.1183/13993003.congress-2016.PA4393

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Response to bronchodilators in school children with asthma and normal FEV1
Aleksandar Kamenov, Svetlana Kamenov, Milan Tosic, Ivana Vidanovic, Borislav Kamenov
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4393; DOI: 10.1183/13993003.congress-2016.PA4393
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More in this TOC Section

  • Asthma phenotypes in children: Allergic versus non allergic
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Show more 7.2 Paediatric Asthma and Allergy

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