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Lung clearance index in asthmatic patients

Luigi Lubrano, Sonia Volpi, Elisa Andreatta, Antonella Borruso, Elena Spinelli, Corrado Vassanelli, Ugo Pradal, Ciro D'Orazio
European Respiratory Journal 2016 48: PA4372; DOI: 10.1183/13993003.congress-2016.PA4372
Luigi Lubrano
1Dipartimento di Scienze Chirurgiche, Odontostomatologiche e Materno-Infantili, Università Degli Studi di Verona, Verona, VRItaly
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Sonia Volpi
2Dipartimento ad Attività Integrata Cardiovascolare e Toracico - Centro Fibrosi Cistica, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, VRItaly
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Elisa Andreatta
1Dipartimento di Scienze Chirurgiche, Odontostomatologiche e Materno-Infantili, Università Degli Studi di Verona, Verona, VRItaly
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Antonella Borruso
2Dipartimento ad Attività Integrata Cardiovascolare e Toracico - Centro Fibrosi Cistica, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, VRItaly
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Elena Spinelli
2Dipartimento ad Attività Integrata Cardiovascolare e Toracico - Centro Fibrosi Cistica, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, VRItaly
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Corrado Vassanelli
2Dipartimento ad Attività Integrata Cardiovascolare e Toracico - Centro Fibrosi Cistica, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, VRItaly
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Ugo Pradal
2Dipartimento ad Attività Integrata Cardiovascolare e Toracico - Centro Fibrosi Cistica, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, VRItaly
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Ciro D'Orazio
2Dipartimento ad Attività Integrata Cardiovascolare e Toracico - Centro Fibrosi Cistica, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, VRItaly
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Abstract

INTRODUCTION Over the last decade the study of pulmonary function by multiple breath washout technique (MBW) has been widely used to detect early pulmonary changes in Cystic Fibrosis. On the contrary there are only few studies that use Lung Clearance Index (LCI) in other chronic lung diseases like asthma. Moreover data regarding bronchodilator response on LCI are contradictory.

AIMS AND OBJECTIVES To find out whether LCI was able to detect any early involvement of small airways in stable asthmatic children and if was more sensitive than spirometry to detect bronchoreversibility after salbutamol administration.

METHODS We performed spirometry and N2-Multiple Breath Wash Out (N2-MBW, Exhalyzer D, Ecomedix) in a group of stable asthmatic patients and in a group of healthy children. In the first group we repeated spirometry and N2-MBW after administration of 400μg of salbutamol

RESULTS 12 asthmatic children (mean age: 6.0 yrs) and 9 healthy controls (mean age: 5.4 yrs) were tested. Basal FEV1 and basal LCI were no statistically different between the 2 groups. After the administration of Salbutamol the increase of FEV1 was of 5%. Among the asthmatic group LCI after the administration of salbutamol showed a statistically significant decrease (p=0.009)

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CONCLUSIONS Our data showed that basal LCI was not different between the two groups. In asthmatic patients it could be more sensitive then spirometry in detecting bronchoreversibility.

  • Asthma - diagnosis
  • Lung function testing
  • Children
  • Copyright ©the authors 2016
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Lung clearance index in asthmatic patients
Luigi Lubrano, Sonia Volpi, Elisa Andreatta, Antonella Borruso, Elena Spinelli, Corrado Vassanelli, Ugo Pradal, Ciro D'Orazio
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4372; DOI: 10.1183/13993003.congress-2016.PA4372

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Lung clearance index in asthmatic patients
Luigi Lubrano, Sonia Volpi, Elisa Andreatta, Antonella Borruso, Elena Spinelli, Corrado Vassanelli, Ugo Pradal, Ciro D'Orazio
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4372; DOI: 10.1183/13993003.congress-2016.PA4372
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