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Hs-CRP in early childhood wheezing

Anette Määttä, Anne Kotaniemi-Syrjänen, Kristiina Malmström, L. Pekka Malmberg, Anna S. Pelkonen, Mika J. Mäkelä
European Respiratory Journal 2016 48: PA4366; DOI: 10.1183/13993003.congress-2016.PA4366
Anette Määttä
1Pediatric Unit, Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Anne Kotaniemi-Syrjänen
1Pediatric Unit, Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Kristiina Malmström
1Pediatric Unit, Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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L. Pekka Malmberg
1Pediatric Unit, Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Anna S. Pelkonen
1Pediatric Unit, Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Mika J. Mäkelä
1Pediatric Unit, Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Abstract

Introduction: High-sensitivity C -reactive protein (hs-CRP) is a biomarker reflecting low-grade systemic inflammation, but its role among wheezing infants is still unknown.

Objective: To demonstrate, whether hs-CRP has any association with recurrent wheezing, atopic markers, baseline lung function, or airway responsiveness in infants with persistent or recurrent lower airway symptoms.

Methods: 62 consecutive steroid-free infants aged 6-27 months (median 15, interquartile range 14;17 months) with persistent or recurrent lower airway symptoms underwent whole body plethysmography, rapid thoracoabdominal compression, methacholine challenge, and skin-prick tests (SPT). Total immunoglobulin E (IgE), blood eosinophils, and hs-CRP were determined.

Results: Recurrent physician-diagnosed wheezing (≥3 wheezing episodes) and blood eosinophilia (eosinophils ≥0.4 x 109/l and ≥4%) were associated with undetectable hs-CRP (n=9/52, p=0.044; n=13/49, p=0.013). Hs-CRP was not associated with atopic eczema, IgE, SPT positivity, or baseline lung function. The infants with blood eosinophilia and increased airway responsiveness to methacholine (PD40V'maxFRC <0.9 mg) also had significantly lower hs-CRP values than those without (n=8/54, p=0.019).

Conclusions: There was no evidence of low-grade systemic inflammation in symptomatic children with recurrent wheezing, blood eosinophilia, or eosinophilia and increased airway responsiveness. Neither was hs-CRP associated with other atopic markers or baseline lung function. In this age group, inflammation of the airways may not be reflected as low-grade systemic inflammation, thus explaining nearly undetectable hs-CRP.

  • Biomarkers
  • Infants
  • Lung function testing
  • Copyright ©the authors 2016
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Hs-CRP in early childhood wheezing
Anette Määttä, Anne Kotaniemi-Syrjänen, Kristiina Malmström, L. Pekka Malmberg, Anna S. Pelkonen, Mika J. Mäkelä
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4366; DOI: 10.1183/13993003.congress-2016.PA4366

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Hs-CRP in early childhood wheezing
Anette Määttä, Anne Kotaniemi-Syrjänen, Kristiina Malmström, L. Pekka Malmberg, Anna S. Pelkonen, Mika J. Mäkelä
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4366; DOI: 10.1183/13993003.congress-2016.PA4366
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