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Evolution of COPD phenotypes in time - Czech multicentre research database of severe COPD

Vladimír Koblízek, Barbora Novotna, Jan Svancara, Michal Svoboda, Patrice Popelkova, Marek Plutinsky, Kristian Brat, Jaromir Zatloukal, Eva Volakova, Karel Hejduk, Eva Kocova, Michal Kopecky, Katerina Neumannova, Miroslava Fecaninova, Petr Safranek, Tomas Dvorak, Ondrej Sobotik, Zuzana Liptakova, Lucie Heribanova, Blanka Snelerova, Marie Majerciakova, Pavlina Musilova, Jiri Jarkovsky
European Respiratory Journal 2016 48: PA4179; DOI: 10.1183/13993003.congress-2016.PA4179
Vladimír Koblízek
1Pulmonary Department, University Hospital Hradec Kralove, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic
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Barbora Novotna
1Pulmonary Department, University Hospital Hradec Kralove, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic
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Jan Svancara
2Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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Michal Svoboda
2Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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Patrice Popelkova
3Pulmonary Department, University Hospital, Ostrava, Czech Republic
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Marek Plutinsky
4Pulmonary Department, University Hospital, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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Kristian Brat
4Pulmonary Department, University Hospital, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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Jaromir Zatloukal
5Pulmonary Department, University Hospital, Faculty of Medicine, Palacky University, Olomouc, Czech Republic
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Eva Volakova
5Pulmonary Department, University Hospital, Faculty of Medicine, Palacky University, Olomouc, Czech Republic
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Karel Hejduk
2Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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Eva Kocova
6Radiology Department, University Hospital Hradec Kralove, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic
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Michal Kopecky
1Pulmonary Department, University Hospital Hradec Kralove, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic
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Katerina Neumannova
7Faculty of Physical Culture, Palacký University, Olomouc, Czech Republic
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Miroslava Fecaninova
8Pulmonary Department, Metropolitan Hospital Bulovka, Praha, Czech Republic
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Petr Safranek
9Pulmonary Department, University Hospital Plzen, Charles University in Prague, Faculty of Medicine in Plzen, Plzen, Czech Republic
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Tomas Dvorak
10Pulmonary Department, Klaudian Hospital, Mlada Boleslav, Czech Republic
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Ondrej Sobotik
11Pulmonary Department, University Hospital Motol, Charles University in Prague, 2nd Faculty of Medicine, Praha, Czech Republic
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Zuzana Liptakova
12Sanatorium for tuberculosis and Respiratory Diseases, Regional Hospital, Ceske Budejovice, Czech Republic
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Lucie Heribanova
13Department of Respiratory Medicine, Thomayer Hospital, Charles University in Prague, 1st Faculty of Medicine, Praha, Czech Republic
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Blanka Snelerova
14Pulmonary Department, Regional Masaryk Hospital, Usti nad Labem, Czech Republic
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Marie Majerciakova
15Pulmonary Departtment, Regional T.Bata Hospital, Zlin, Czech Republic
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Pavlina Musilova
16Pulmonary Department, Regional Hospital, Jihlava, Czech Republic
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Jiri Jarkovsky
2Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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Abstract

Background: COPD is a condition with several clinical variants:non-exacerbation phenotype(NON-AE),frequent exacerbations with chronic bronchitis(AE CB),frequent exacerbations without chronic bronchitis(AE NON-CB),and asthma–COPD overlap syndrome(ACOS).The evolution of COPD phenotypes in time and their impact on lung function and symptoms remains largely unknown.

Methods: The Czech Research Database of COPD(NCT01923051)is a multicentre,observational,and prospective study of consecutive patients with severe COPD.Signs identifying phenotypes, lung function, and respiratory symptoms were assessed annually.

Results: 647 severe COPD subjects were enrolled until Jan 16. 113 of them were eligible for two-year analysis (66.8±9.1yrs,73.8% males,post-BD FEV1 43.0±17.7%).On the whole 62.6% were NON-AE,18.8% were AE CB, 7.1% were AE NON-CB,and 11.5 % were ACOS subjects.We found apparent differences in term of COPD phenotypes stability during follow-up.There were stable (ACOS,and NON-AE) and unstable (AE CB, and AE NON-CB) phenotypes (Fig1). With respect to changes of lung function and symptoms we noted significant differences between above mentioned phenotypes.

Conclusion: Two clinical phenotypes (ACOS and NON-AE) of subjects with severe COPD we can described as stable over time.Significant differences in FEV1 declination and symptoms evolution between different COPD phenotypes in the prospective two-year evaluation were noted.

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  • COPD - diagnosis
  • COPD - exacerbations
  • Lung function testing
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Evolution of COPD phenotypes in time - Czech multicentre research database of severe COPD
Vladimír Koblízek, Barbora Novotna, Jan Svancara, Michal Svoboda, Patrice Popelkova, Marek Plutinsky, Kristian Brat, Jaromir Zatloukal, Eva Volakova, Karel Hejduk, Eva Kocova, Michal Kopecky, Katerina Neumannova, Miroslava Fecaninova, Petr Safranek, Tomas Dvorak, Ondrej Sobotik, Zuzana Liptakova, Lucie Heribanova, Blanka Snelerova, Marie Majerciakova, Pavlina Musilova, Jiri Jarkovsky
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4179; DOI: 10.1183/13993003.congress-2016.PA4179

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Evolution of COPD phenotypes in time - Czech multicentre research database of severe COPD
Vladimír Koblízek, Barbora Novotna, Jan Svancara, Michal Svoboda, Patrice Popelkova, Marek Plutinsky, Kristian Brat, Jaromir Zatloukal, Eva Volakova, Karel Hejduk, Eva Kocova, Michal Kopecky, Katerina Neumannova, Miroslava Fecaninova, Petr Safranek, Tomas Dvorak, Ondrej Sobotik, Zuzana Liptakova, Lucie Heribanova, Blanka Snelerova, Marie Majerciakova, Pavlina Musilova, Jiri Jarkovsky
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4179; DOI: 10.1183/13993003.congress-2016.PA4179
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