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CAT in COPD phenotypes (POPE study)

Vladimír Koblízek, Attila Somfay, Jan Svancara, Ruzena Tkacova, Branislava Milenkovic, Adam Barczyk, Kirill Zykov, Neven Tudoric, Kosta Kostov, Zuzana Zbozinkova, Jurij Sorli, Alvis Krams, Marc Miravitlles, Arschang Valipour
European Respiratory Journal 2016 48: PA4177; DOI: 10.1183/13993003.congress-2016.PA4177
Vladimír Koblízek
1Department of Pneumology, University Hospital Hradec Kralove, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic
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Attila Somfay
2Department of Pulmonology, University of Szeged, Deszk, Hungary
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Jan Svancara
3Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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Ruzena Tkacova
4Department of Respiratory Medicine, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia
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Branislava Milenkovic
5Clinic for Pulmonary Diseases, Clinical Centre of Serbia, Belgrade, Republic of Serbia
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Adam Barczyk
6Department of Pneumology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
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Kirill Zykov
7Laboratory of Pulmonology, Moscow State University of Medicine and Dentistry Named After A.I.Evdokimov, Moscow, Russian Federation
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Neven Tudoric
8School of Medicine Zagreb, University Hospital Dubrava, Zagreb, Croatia
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Kosta Kostov
9Pulmonary Diseases Clinic, Military Medical Academy, Sofia, Bulgaria
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Zuzana Zbozinkova
3Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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Jurij Sorli
10Pulmonary Department, Topolsica Hospital, Topolsica, Slovenia
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Alvis Krams
11Faculty of Medicine, University of Latvia, Riga, Latvia
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Marc Miravitlles
12Pneumology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain
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Arschang Valipour
13Department of Respiratory and Critical Care Medicine, Ludwig-Boltzmann-Institute for COPD and Respiratory Epidemiology, Otto-Wagner-Spital, Wien, Austria
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Abstract

Background: The COPD assessment test (CAT) is widely used for basic symptom evaluation in patients with COPD. The impact of COPD phenotypes on symptom scores using the CAT, however, remains largely unknown.

Methods: The POPE-Study (NCT02119494) is an international, multicentre, observational cross-sectional survey of consecutive patients with COPD in Central and Eastern Europe (CEE). Respiratory symptoms using the modified Medical Research Council (mMRC) dyspnoea scale, and the CAT were recorded. Inclusion criteria: age ≥ 40 years, smoking history ≥ 10 pack-years, post-bronchodilator (BD) FEV1/FVC < 0.7, and ≥ 4 weeks absence of exacerbation. The relationship between predefined phenotypes and CAT score items was assessed. In addition to total CAT score, all eight CAT sub-items (CAT 1 – CAT 8) are separately noted.

Results: 3366 COPD subjects (66 ± 8.8 yrs, post-BD FEV1 52.8 ± 18.5 % predicted, CAT 17.4 ± 7.8) were recruited. On the whole 63.3 % were non-exacerbators (NON-AE), 20.4 % frequent exacerbators with chronic bronchitis (AE CB), 9.5 % frequent exacerbators without CB (AE NON-CB), and 6.9 % were patients with asthma-COPD overlap syndrome (ACOS). There were apparent statistically significant differences (< 0.001) in total CAT and individual items of the score between phenotypes. According to results of univariate and multivatriate logistics regression some items of CAT scores are good predictors of COPD phenotypes, e.g. if CAT 3 tightness on chest grew by 1 point, probability of being non-exacerbator was 10-20% lower.

Conclusion: There were noted significant differences in total CAT and individual CAT items between clinical phenotypes of COPD.

  • COPD - diagnosis
  • COPD - management
  • COPD - exacerbations
  • Copyright ©the authors 2016
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CAT in COPD phenotypes (POPE study)
Vladimír Koblízek, Attila Somfay, Jan Svancara, Ruzena Tkacova, Branislava Milenkovic, Adam Barczyk, Kirill Zykov, Neven Tudoric, Kosta Kostov, Zuzana Zbozinkova, Jurij Sorli, Alvis Krams, Marc Miravitlles, Arschang Valipour
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4177; DOI: 10.1183/13993003.congress-2016.PA4177

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CAT in COPD phenotypes (POPE study)
Vladimír Koblízek, Attila Somfay, Jan Svancara, Ruzena Tkacova, Branislava Milenkovic, Adam Barczyk, Kirill Zykov, Neven Tudoric, Kosta Kostov, Zuzana Zbozinkova, Jurij Sorli, Alvis Krams, Marc Miravitlles, Arschang Valipour
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4177; DOI: 10.1183/13993003.congress-2016.PA4177
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