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Variability of total serum IgE in moderate-to-severe asthmatic patients

Renaud Louis, Charles Pilette, Olivier Michel, Alain Michils, Guy Brusselle, Lieven Dupont, Antoine Poskin, Jan Van Schoor, Stefaan Vancayzeele, Sandra Gurdain
European Respiratory Journal 2016 48: PA4171; DOI: 10.1183/13993003.congress-2016.PA4171
Renaud Louis
1Pneumologie-Allergologie, CHU de Liège, Liege, Belgium
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Charles Pilette
2Pneumologie, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Olivier Michel
3Laboratory of Experimental Medicine, CHU Brugmann, Brussels, Belgium
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Alain Michils
4Pneumologie, Hôpital Erasme, Brussels, Belgium
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Guy Brusselle
5Longziekten, UZ Gent, Ghent, East FlandersBelgium
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Lieven Dupont
6Pneumologie, UZ Leuven, Leuven, Flemish BrabantBelgium
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Antoine Poskin
7Therapeutic Area Respiratory, Novartis, Vilvoorde, Flemish BrabantBelgium
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Jan Van Schoor
7Therapeutic Area Respiratory, Novartis, Vilvoorde, Flemish BrabantBelgium
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Stefaan Vancayzeele
7Therapeutic Area Respiratory, Novartis, Vilvoorde, Flemish BrabantBelgium
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Sandra Gurdain
7Therapeutic Area Respiratory, Novartis, Vilvoorde, Flemish BrabantBelgium
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Abstract

Long-term variability of serum total IgE (sIgEtot) has been reported in asthmatics. This study evaluates the dynamics and the factors predictive of this variability.

sIgEtot levels were prospectively measured over 1 year in 41 moderate-to-severe asthmatics treated with high-dose of inhaled corticosteroids and long-acting β2 agonists (and untreated with omalizumab). Patients were divided into 3 groups according to their baseline sIgEtot level: low (≤75 IU/mL; n=10), intermediate (76-700 IU/mL; n=20) or high (>700 IU/mL; n=11). The sIgEtot variability and factors predictive of IgEtot variability were studied.

The mean sIgEtot (whole group) fluctuated over 1 year and showed an overall non-significant decrease from baseline (p=0.21). Four to 29% of the sIgEtot variability depended on within-patient variability. No factor predictive of the within-patient variability was identified in the intermediate sIgEtot group. In the low sIgEtot group, however, the level of sIgEtot increased over 1 year in patients exposed to allergens (p<0.001) or who used oral corticosteroids (OCS) (p=0.011), and the odds of having an exacerbation since the previous visit increased by 30% if sIgEtot increased by 100 IU/mL (p<0.0001). Unexpectedly, in the high sIgEtot group, the odds of having an exacerbation since the previous visit decreased by 5% if sIgEtot increased by 100 IU/mL (p=0.005). These trends should be confirmed in a bigger cohort.

In this small cohort of moderate-to-severe asthmatics, a limited within-patient variability of sIgEtot levels was observed over 1 year. This variability depended on allergen exposure, OCS use (probably related to exacerbation management) and exacerbations in patients with low and high baseline sIgEtot.

  • Asthma - mechanism
  • Allergy
  • Immunology
  • Copyright ©the authors 2016
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Variability of total serum IgE in moderate-to-severe asthmatic patients
Renaud Louis, Charles Pilette, Olivier Michel, Alain Michils, Guy Brusselle, Lieven Dupont, Antoine Poskin, Jan Van Schoor, Stefaan Vancayzeele, Sandra Gurdain
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4171; DOI: 10.1183/13993003.congress-2016.PA4171

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Variability of total serum IgE in moderate-to-severe asthmatic patients
Renaud Louis, Charles Pilette, Olivier Michel, Alain Michils, Guy Brusselle, Lieven Dupont, Antoine Poskin, Jan Van Schoor, Stefaan Vancayzeele, Sandra Gurdain
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4171; DOI: 10.1183/13993003.congress-2016.PA4171
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