Abstract
Background: Pneumococcal infections cause high morbidity and mortality. By WHO estimations the only efficient way to influence the level of pneumococcal infection morbidity is vaccination.
Aim: To assess clinical and social-economic efficiency of pneumococcal vaccination among the children of the Amur region (Russia).
Methods: 4988 children at the age of 2-5 years who had risk factors of pneumococcal infection were included in the program of monitoring and clinical-epidemiological assessment of efficiency of vaccination with the use of “Prevenar-13” that was done during and after the large flooding of the rivers Zeya and Amur in 2013. Data of vaccinated children were analyzed during the year before in a year after vaccination with the use of special criteria: coefficient of prophylactic effectiveness (CPE) of vaccination and infection index (InI).
Results: In postvaccinal period the total duration of illness of acute respiratory infections decreased by 14.6%; the number of courses with antibacterial therapy lowered by 21.3%, the number of cases of hospital admission lowered by 38.4%. The number of registered pneumonias decreased in 2.3 times. CPE of vaccination by the pneumonia morbidity reached the level of 75-100%. Direct dependence of CPE of vaccination on the age of children was found out (R=1.0). InI among children older than 5 years was 0.31, which was 4.5 times less than among children younger than 2 years (1,4). InI value had a strong negative dependence on the age (R=-1.0).
Conclusion: The obtained results allows to recommend the conjugated vaccine “Prevenar-13” as an effective method of prevention of pneumonia in the complex of antiepidemic and preventive measures.
- Copyright ©the authors 2016
