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Clinical and epidemiological assessment of the regional program of vaccination for pneumococcal infections

Victor Kolosov, Leonid Manakov, Olga Kurganova, Juliy Perelman
European Respiratory Journal 2016 48: PA4158; DOI: 10.1183/13993003.congress-2016.PA4158
Victor Kolosov
1Laboratory of Prophylaxis of Nonspecific Lung Diseases, Far Eastern Scientific Center of Physiology and Pathology of Respiration, Blagoveshchensk, Russian Federation
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Leonid Manakov
1Laboratory of Prophylaxis of Nonspecific Lung Diseases, Far Eastern Scientific Center of Physiology and Pathology of Respiration, Blagoveshchensk, Russian Federation
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Olga Kurganova
3Administration, Federal Service on Customers Rights Protection and Human Well-Being Surveillance in the Amur Region, Blagoveshchensk, Russian Federation
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Juliy Perelman
2Laboratory of Functional Research of Respiratory System, Far Eastern Scientific Center of Physiology and Pathology of Respiration, Blagoveshchensk, Russian Federation
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Abstract

Background: Pneumococcal infections cause high morbidity and mortality. By WHO estimations the only efficient way to influence the level of pneumococcal infection morbidity is vaccination.

Aim: To assess clinical and social-economic efficiency of pneumococcal vaccination among the children of the Amur region (Russia).

Methods: 4988 children at the age of 2-5 years who had risk factors of pneumococcal infection were included in the program of monitoring and clinical-epidemiological assessment of efficiency of vaccination with the use of “Prevenar-13” that was done during and after the large flooding of the rivers Zeya and Amur in 2013. Data of vaccinated children were analyzed during the year before in a year after vaccination with the use of special criteria: coefficient of prophylactic effectiveness (CPE) of vaccination and infection index (InI).

Results: In postvaccinal period the total duration of illness of acute respiratory infections decreased by 14.6%; the number of courses with antibacterial therapy lowered by 21.3%, the number of cases of hospital admission lowered by 38.4%. The number of registered pneumonias decreased in 2.3 times. CPE of vaccination by the pneumonia morbidity reached the level of 75-100%. Direct dependence of CPE of vaccination on the age of children was found out (R=1.0). InI among children older than 5 years was 0.31, which was 4.5 times less than among children younger than 2 years (1,4). InI value had a strong negative dependence on the age (R=-1.0).

Conclusion: The obtained results allows to recommend the conjugated vaccine “Prevenar-13” as an effective method of prevention of pneumonia in the complex of antiepidemic and preventive measures.

  • Vaccination
  • Public health
  • Epidemiology
  • Copyright ©the authors 2016
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Clinical and epidemiological assessment of the regional program of vaccination for pneumococcal infections
Victor Kolosov, Leonid Manakov, Olga Kurganova, Juliy Perelman
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4158; DOI: 10.1183/13993003.congress-2016.PA4158

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Clinical and epidemiological assessment of the regional program of vaccination for pneumococcal infections
Victor Kolosov, Leonid Manakov, Olga Kurganova, Juliy Perelman
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4158; DOI: 10.1183/13993003.congress-2016.PA4158
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