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Fibroblast growth factor 9 (FGF9) modulates mesothelial cells plasticity to decrease differentiation and migration in vitro

Audrey Joannes, Aurélien Justet, Philippe Bonniaud, Jean Michel Sallenave, Bruno Crestani, Arnaud Mailleux
European Respiratory Journal 2016 48: PA4033; DOI: 10.1183/13993003.congress-2016.PA4033
Audrey Joannes
1INSERM U1152, Université Paris Diderot, DHU Fire, LabEx Inflamex, Paris, France
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Aurélien Justet
1INSERM U1152, Université Paris Diderot, DHU Fire, LabEx Inflamex, Paris, France
2Service de Pneumologie A, Hôpital Bichat, Université Paris Diderot, DHU Fire, LabEx Inflamex, Paris, France
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Philippe Bonniaud
3INSERM U866, “Lipide Nutrition Cancer”, Equipe “Protéines de Choc Thermique: Mort Cellulaire, Différenciation Cellulaire et Propriétés Tumorigéniques”, Faculté de Médecine et de Pharmacie, Dijon, France
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Jean Michel Sallenave
1INSERM U1152, Université Paris Diderot, DHU Fire, LabEx Inflamex, Paris, France
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Bruno Crestani
1INSERM U1152, Université Paris Diderot, DHU Fire, LabEx Inflamex, Paris, France
2Service de Pneumologie A, Hôpital Bichat, Université Paris Diderot, DHU Fire, LabEx Inflamex, Paris, France
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Arnaud Mailleux
1INSERM U1152, Université Paris Diderot, DHU Fire, LabEx Inflamex, Paris, France
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Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and lethal lung disease of unknown etiology. IPF begins in the subpleural region and extends centrally. Pleural mesothelial cells may contribute to pleural fibrosis. Key developmental lung signalling pathways such as FGFs are reactivated in IPF. During lung development, FGF9 is expressed in mesothelium and is implicated in the control of epithelial branching and mesenchymal proliferation. We observed that FGF9 is reactivated in pleural cells in IPF patients compared to controls. In this study, we investigated the effects of FGF9 on rat mesothelial cells proliferation, differentiation, and migration in vitro.

In basal condition, mesothelial cells mostly expressed receptors with a high affinity for FGF9 (FGFR3IIIc>FGFR2IIIc>FGFR1IIIc). TGFβ1 (5ng/ml) decreased the expression of FGFR3IIIc while FGFR4 expression was increased. In basal condition, FGF9 (20ng/ml) activated p-Erk, did not influence mesothelial cell proliferation, decreased Collagen-1 production, decreased α-smooth muscle actin (α-SMA) and Wilms tumor (WT1) expression and decreased mesothelial cells migratory abilities. FGF9 also partially prevented TGFβ1-induced mesothelial cell differentiation (collagen-1 expression) and migration upregulation.

These results suggest that FGF9 modulates mesothelial cells plasticity to maintain an undifferentiated and anti-migratory phenotype and could have an antifibrogenic role in the early phase of IPF.

  • Cell biology
  • Idiopathic pulmonary fibrosis
  • Pleura
  • Copyright ©the authors 2016
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Fibroblast growth factor 9 (FGF9) modulates mesothelial cells plasticity to decrease differentiation and migration in vitro
Audrey Joannes, Aurélien Justet, Philippe Bonniaud, Jean Michel Sallenave, Bruno Crestani, Arnaud Mailleux
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4033; DOI: 10.1183/13993003.congress-2016.PA4033

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Fibroblast growth factor 9 (FGF9) modulates mesothelial cells plasticity to decrease differentiation and migration in vitro
Audrey Joannes, Aurélien Justet, Philippe Bonniaud, Jean Michel Sallenave, Bruno Crestani, Arnaud Mailleux
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4033; DOI: 10.1183/13993003.congress-2016.PA4033
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  • Cryptotanshinone attenuates airway Inflammation induced by cigarette smoke in mice
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