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Preclinical studies of mesenchymal stem cell (MSC) transplantation in chronic obstructive pulmonary disease (COPD): A systematic review and meta-analysis

Hui jung Kim, Xiangde Liu
European Respiratory Journal 2016 48: PA4017; DOI: 10.1183/13993003.congress-2016.PA4017
Hui jung Kim
1Pulmonary and Critical Care Division, WonKwang University, Sanbon Medical Center, Gunpo, Republic of Korea
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Xiangde Liu
2Pulmonary and Critical Care Division, University of Nebraska Medical Center, Omaha, NEUnited States
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Abstract

Background Aim of the current study was to systematically review and to conduct meta-analysis on the published pre-clinical studies of MSC treatment in COPD animal models

Methods: and Results Statistical analysis was performed using the Comprehensive Meta-Analysis software (Version 3). The pooled Hedges's g with 95% confidence intervals (95% CIs) was adopted to assess the effect size. Random effect model was used due to the heterogeneity between the studies. A total of 20 eligible studies were included in the current systematic review and overall meta-analysis showed that MSC administration was significantly in favor of attenuating acute lung injury (Hedges's g = -2.325 ± 0.145 with 95% CI: -2.609 ∼ -2.040, P< 0.001 for mean linear intercept, MLI; Hedges's g = -3.488 ± 0.504 with 95% CI: -4.476 ∼ -2.501, P< 0.001 for TUNEL staining), stimulating lung tissue repair (Hedges's g = 3.249 ± 0.586 with 95% CI: 2.103∼ 4.394, P < 0.001) and improving lung function (Hedges's g = 2.053 ± 0.408 with 95% CI: 1.253 ∼ 2.854, P< 0.001). The mechanism of MSC therapy in COPD seems to be ameliorating airway inflammation (Hedges's g = -2.956 ± 0.371 with 95% CI: -3.683 ∼ -2.229, P< 0.001) and stimulating cytokine synthesis that involves in lung tissue repair (Hedges's g = 3.103 ± 0.734 with 95% CI: 1.664 ∼ 4.541, P< 0.001)

Conclusion: These pre-clinical studies demonstrated that MSC hold promise in the treatment of chronic lung diseases including COPD. The mechanisms of MSCs in pre-clinical COPD treatment may be associated with attenuating airway inflammation as well as stimulating lung tissue repair.

  • Lung injury
  • COPD - mechanism
  • COPD - management
  • Copyright ©the authors 2016
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Preclinical studies of mesenchymal stem cell (MSC) transplantation in chronic obstructive pulmonary disease (COPD): A systematic review and meta-analysis
Hui jung Kim, Xiangde Liu
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4017; DOI: 10.1183/13993003.congress-2016.PA4017

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Preclinical studies of mesenchymal stem cell (MSC) transplantation in chronic obstructive pulmonary disease (COPD): A systematic review and meta-analysis
Hui jung Kim, Xiangde Liu
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4017; DOI: 10.1183/13993003.congress-2016.PA4017
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