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The effects of endogenous and exogenous vitamin D on the rate of mature elastin degradation in COPD patients

Rob Janssen, Ruben Zaal, Michiel Spanbroek, Jody van den Ouweland, Pieter Zanen, Richard Dekhuijzen, Wim Janssens
European Respiratory Journal 2016 48: PA4015; DOI: 10.1183/13993003.congress-2016.PA4015
Rob Janssen
Department of Pulmonary Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands
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Ruben Zaal
Department of Pulmonary Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands
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Michiel Spanbroek
Department of Pulmonary Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands
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Jody van den Ouweland
Department of Clinical Chemistry, Canisius Wilhelmina Hospital, Nijmegen, Netherlands
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Pieter Zanen
Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, Netherlands
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Richard Dekhuijzen
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
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Wim Janssens
Laboratory of Respiratory Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
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Abstract

Introduction: Two RCTs suggest that vitamin D supplementation lowers exacerbation frequency in vitamin D deficient COPD patients (Lehouck, A. et al. Ann Intern Med 2012; 156:105-14/Martineau, A.R. et al. Lancet Respir Med 2015; 3:e24-5). However, information regarding the effect of vitamin D on the rate of mature elastin degradation is lacking. We hypothesized that vitamin D supplementation in vitamin D deficient (serum 25-[OH]D<20 ng/mL) COPD patients reduces the rate of mature elastin degradation quantified by plasma desmosines levels (pDES).

Methods: pDES was measured by LC-MS/MS in 142 COPD patients from the Leuven vitamin D intervention trial (100,000 IU vitamin D supplementation or placebo every 4 weeks for 1 year).

Results: At baseline, no significant correlation was found between 25-[OH]D and pDES levels. No significant interaction between 25-[OH]D change and pDES change was found in the placebo arm. In the vitamin D supplementation arm, a significant negative association was found between pDES change and baseline 25-[OH]D levels (r=-0.44;p<0.001;n=56). Conclusions Endogenous vitamin D did not have an effect on the rate of mature elastin degradation. However, opposite to our hypothesis, exogenous high doses of vitamin D accelerated the rate of mature elastin degradation in vitamin D deficient COPD patients and decelerated this process in those who were vitamin D sufficient at baseline.

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The effects of endogenous and exogenous vitamin D on the rate of mature elastin degradation in COPD patients
Rob Janssen, Ruben Zaal, Michiel Spanbroek, Jody van den Ouweland, Pieter Zanen, Richard Dekhuijzen, Wim Janssens
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4015; DOI: 10.1183/13993003.congress-2016.PA4015

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The effects of endogenous and exogenous vitamin D on the rate of mature elastin degradation in COPD patients
Rob Janssen, Ruben Zaal, Michiel Spanbroek, Jody van den Ouweland, Pieter Zanen, Richard Dekhuijzen, Wim Janssens
European Respiratory Journal Sep 2016, 48 (suppl 60) PA4015; DOI: 10.1183/13993003.congress-2016.PA4015
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