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Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer

Adem Karaman, Irmak Durur-Subasi, Fatih Alper, Omer Araz, Mahmut Subasi, Elif Demirci, Mevlut Albayrak, Gokhan Polat, Metin Akgün, Nevzat Karabulut
European Respiratory Journal 2016 48: PA3813; DOI: 10.1183/13993003.congress-2016.PA3813
Adem Karaman
1Radiology, Ataturk University, Erzurum, Turkey
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Irmak Durur-Subasi
1Radiology, Ataturk University, Erzurum, Turkey
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Fatih Alper
1Radiology, Ataturk University, Erzurum, Turkey
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Omer Araz
2Pulmonary Diseases, Ataturk University, Erzurum, Turkey
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Mahmut Subasi
3Thoracic Surgery, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
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Elif Demirci
4Pathology, Atatürk University, Erzurum, Turkey
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Mevlut Albayrak
4Pathology, Atatürk University, Erzurum, Turkey
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Gokhan Polat
1Radiology, Ataturk University, Erzurum, Turkey
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Metin Akgün
2Pulmonary Diseases, Ataturk University, Erzurum, Turkey
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Nevzat Karabulut
5Radiology, Pamukkale University, Denizli, Turkey
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Abstract

The primary objective of the study was to evaluate the association between the minimum apparent diffusion coefficient (ADCmin) and Ki-67, an index for cellular proliferation, in non-small cell lung cancers. Also, we aimed to assess whether ADCmin values differ between tumour subtypes and tissue sampling method.

The patients who had diffusion weighted magnetic resonance imaging (DW-MRI) were enrolled retrospectively. The correlation between ADCmin and the Ki-67 index was evaluated.

Ninety three patients, with a mean age 65 ± 11 years, with histopathologically proven adenocarcinoma and squamous cell carcinoma of the lungs and had technically successful DW-MRI were included in the study. The numbers of tumour subtypes were 47 for adenocarcinoma and 46 for squamous cell carcinoma. There was a good negative correlation between ADCmin values and the Ki-67 proliferation index (r = -0.837, p < 0.001). The mean ADCmin value was higher and the mean Ki-67 index was lower in adenocarcinomas compared to squamous cell carcinoma (p < 0.0001). There was no statistical difference between tissue sampling methods.

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Because ADCmin shows a good but negative correlation with Ki-67 index, it provides an opportunity to evaluate tumours and their aggressiveness and may be helpful in the differentiation of subtypes non-invasively.

  • Lung cancer / Oncology
  • Imaging
  • Neoplastic diseases
  • Copyright ©the authors 2016
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Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer
Adem Karaman, Irmak Durur-Subasi, Fatih Alper, Omer Araz, Mahmut Subasi, Elif Demirci, Mevlut Albayrak, Gokhan Polat, Metin Akgün, Nevzat Karabulut
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3813; DOI: 10.1183/13993003.congress-2016.PA3813

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Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer
Adem Karaman, Irmak Durur-Subasi, Fatih Alper, Omer Araz, Mahmut Subasi, Elif Demirci, Mevlut Albayrak, Gokhan Polat, Metin Akgün, Nevzat Karabulut
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3813; DOI: 10.1183/13993003.congress-2016.PA3813
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