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The effect of pulmonary rehabilitation on oxidative stress after acute exacerbation in COPD

Zsuzsanna Kelemen, Orsolya Drozdovszky, Maria Kerti, Zsuzsanna Balogh, Imre Barta, Balazs Antus, János Tamás Varga
European Respiratory Journal 2016 48: PA3786; DOI: 10.1183/13993003.congress-2016.PA3786
Zsuzsanna Kelemen
14th Department of Pulmonology, National Koranyi Institute for TB and Pulmonology, Budapest, Hungary
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Orsolya Drozdovszky
2Department of Pathophysiology, National Koranyi Institute for TB and Pulmonology, Budapest, Hungary
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Maria Kerti
3Department of Pulmonary Rehabilitation, National Koranyi Insitute for TB and Pulmonology, Budapest, Hungary
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Zsuzsanna Balogh
4Department of Pulmonary Rehabilitation, National Koranyi Institute for TB and Pulmonology, Budapest, Hungary
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Imre Barta
5Department of Pathophysiology, National Koranyi Institute for TB and Pulmonology, Budapest, Hungary
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Balazs Antus
6Department of Pathophysiology, National Koranyi Institute for TB and Pulmonology, Budapest, Hungary
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János Tamás Varga
7Department of Pulmonary Rehabilitation, National Koranyi Institute for TB and Pulmonology, Budapest, Hungary
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Abstract

Introduction: Oxidative stress plays an important role in the pathogenesis of COPD and in acute exacerbation of the disease (AECOPD). Pulmonary rehabilitation (PR) has maintenance effect on exercise physiologic parameters in COPD.

Aims: The aim of our study was to investigate the effect of early PR on lung function, exercise physiologic variables and oxidative stress after AECOPD.

Methods: 18 AECOPD patients (FEV1: 45±17, TLCO: 41±16 %pred) were enrolled, 10 patients completed a 6 week standardized PR and 8 patients served as controls (C). Body plethysmography, diffusion capacity and cardio-pulmonary exercise test were carried out and MDA levels in sputum and plasma were measured in a longitudional manner (at the onset of AECOPD (V1), before PR (V2), after PR (V3), at 3 months after PR(V4)).

Results: Lung function parameters did not change significantly in PR and C group. The effect of PR was manifested in WR (V2:52±12 vs. V3:67±5* vs. V4:62±22), VO2/kg (V2:12,1±2,4 vs. V3: 14,1±1,1* vs. V4:13,7±4,5 mL/kg/min., *p<0,05), VO2/HR (V2:7,97±0,85 vs. V3: 8,83±0,70* vs. V4:8,10±2,99, *p<0,05). Sputum MDA was significantly lower after PR compared to C group and it was further reduced at 3 months after PR (PR V3:91±29 vs. V4:71±12*, C V3:154±56 vs. V4:229±31nmol/l, *p<0,05). Plasma MDA was lower after PR compared to C group and was stable at 3 months after PR (PR V3: 93±20 vs. V4: 102±39; C V3: 145±51 vs. V4: 127±23 nmol/l).

Conclusion: Early pulmonary rehabilitation after AECOPD results in favourable exercise physiologic effects that are sustained for at least 3 months after completion of the program. Effective PR may stabilize oxidative stress at a lower level following treatment of AECOPD.

  • COPD - management
  • Rehabilitation
  • Exacerbation
  • Copyright ©the authors 2016
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The effect of pulmonary rehabilitation on oxidative stress after acute exacerbation in COPD
Zsuzsanna Kelemen, Orsolya Drozdovszky, Maria Kerti, Zsuzsanna Balogh, Imre Barta, Balazs Antus, János Tamás Varga
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3786; DOI: 10.1183/13993003.congress-2016.PA3786

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The effect of pulmonary rehabilitation on oxidative stress after acute exacerbation in COPD
Zsuzsanna Kelemen, Orsolya Drozdovszky, Maria Kerti, Zsuzsanna Balogh, Imre Barta, Balazs Antus, János Tamás Varga
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3786; DOI: 10.1183/13993003.congress-2016.PA3786
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