Prevalence of metabolic syndrome in patients with chronic obstructive pulmonary disease

Abstract

Background: Chronic obstructive respiratory disease (COPD) is a major health problem being, worldwide, the fourth leading cause of death and its prevalence tends to increase. There is a limited data concerned with the prevalence of metabolic syndrome in COPD patients. Aim of the study was to determine the prevalence of COPD and the metabolic syndrome with special interest in the coexistence of these two problems as well as the possible links.

Material and methods: This study was conducted in the first Republican Clinical Hospital from 8 September 2014 until 7 November 2015. In this study 92 men and 114 women (aged 42-65 years old; mean age 54.2±12.4;) enrolled. Anthropometric measurements, spirometry, body composition, functional exercise performance, and mood and health status were assessed. Metabolic syndrome was defined by the International Diabetes Federation. All patients completed CAT (COPD assessment test) and mMRC (Modified Medical Research Council Dyspnea scale) questionnaires.

Results: The presence of MS was 38.3% of the COPD patients (p<0.05). The presence of MS is associated with significantly worse cough, sleep and mood (p<0.02) and higher total CAT score (p=0.035). Average BMI is 28.17. There is a correlation between the presence of MS and exacerbations of COPD last two years (p=0.02) and no correlation between the pulmonary function presence of the metabolic syndrome.

Conclusion: The high prevalence of the metabolic syndrome in patients with the COPD in the area show the urgent need to develop comprehensive strategies aimed at prevention and treatment. Correction of the MS may have a significant role in prevention of complications related with the COPD.