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Introducing the Homburg lung: Efficacy and safety of a minimal-invasive system for extracorporeal CO2 removal

Frederik Seiler, Franziska Trudzinski, Annegret Kamp, Konstantinos Tsitouras, Oliver Linn, Carlos Metz, Philip Böhmer, Ralf Kaiser, Sebastian Fähndrich, Heinrike Wilkens, Hendrik Haake, Robert Bals, Philipp Lepper
European Respiratory Journal 2016 48: PA3571; DOI: 10.1183/13993003.congress-2016.PA3571
Frederik Seiler
1Saarland University Medical Center, Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Critical Care Medicine, Homburg, Germany
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Franziska Trudzinski
1Saarland University Medical Center, Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Critical Care Medicine, Homburg, Germany
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Annegret Kamp
1Saarland University Medical Center, Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Critical Care Medicine, Homburg, Germany
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Konstantinos Tsitouras
1Saarland University Medical Center, Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Critical Care Medicine, Homburg, Germany
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Oliver Linn
1Saarland University Medical Center, Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Critical Care Medicine, Homburg, Germany
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Carlos Metz
1Saarland University Medical Center, Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Critical Care Medicine, Homburg, Germany
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Philip Böhmer
1Saarland University Medical Center, Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Critical Care Medicine, Homburg, Germany
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Ralf Kaiser
1Saarland University Medical Center, Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Critical Care Medicine, Homburg, Germany
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Sebastian Fähndrich
1Saarland University Medical Center, Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Critical Care Medicine, Homburg, Germany
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Heinrike Wilkens
1Saarland University Medical Center, Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Critical Care Medicine, Homburg, Germany
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Hendrik Haake
2Klinik für Kardiologie, Elektrophysiologie und Intensivmedizin, Kliniken Maria Hilf, Mönchengladbach, Germany
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Robert Bals
1Saarland University Medical Center, Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Critical Care Medicine, Homburg, Germany
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Philipp Lepper
1Saarland University Medical Center, Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Critical Care Medicine, Homburg, Germany
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Abstract

Introduction: Extracorporeal CO2 removal (ECCO2R) is increasingly used as a therapeutic strategy in hypercapnic lung failure in order to avoid intubation, to allow lung protective ventilator settings, or to facilitate weaning from invasive ventilation. Here, we report on the Homburg Lung, a novel minimal-invasive mid-flow ECCO2R system which was established and successfully used at our ICU. The Homburg Lung is a pump-driven (Maquet Rotaflow) system for veno-venous ECCO2R with ¼” tubing and a 0.8 m2 surface oxygenator (Maquet Quadrox-I pediatric). Vascular access is usually established via a 19F/21cm bilumen cannula in the right internal jugular vein.

Methods: To analyse efficacy and safety of the Homburg Lung, we screened our patient registry for ECCO2R procedures since 2013. Patients who underwent ECMO prior to ECCO2R were excluded. Patients who underwent ECCO2R more than one time since 2013 were only included once.

Results: A total of 19 patients (age 52.3 ± 12.86 years, 42.1% female) was analysed. Ventilatory failure occurred due to COPD (47.4%), cystic fibrosis (21 %), and other origins (31.6%). The system generated a blood flow of 1.23 ± 0.29 lpm. Gas flow was 5.37 ± 2.98 lpm. Within 4 h, pCO2 could be reduced from 74.03 ± 17.51 mmHg to 55.53 ± 10.85 mmHg. Cannulation-associated complications were transient arrhythmia (1/19 patients), pneumothorax (1/19), and air embolism (1/19). Fatal complications were not registered.

Conclusion: The Homburg Lung provides effective CO2 removal in hypercapnic lung failure. The cannulation is a safe procedure with complication rates comparable to those in central venous catheter implantation.

  • Critically ill patients
  • Intensive care
  • Acute respiratory failure
  • Copyright ©the authors 2016
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Introducing the Homburg lung: Efficacy and safety of a minimal-invasive system for extracorporeal CO2 removal
Frederik Seiler, Franziska Trudzinski, Annegret Kamp, Konstantinos Tsitouras, Oliver Linn, Carlos Metz, Philip Böhmer, Ralf Kaiser, Sebastian Fähndrich, Heinrike Wilkens, Hendrik Haake, Robert Bals, Philipp Lepper
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3571; DOI: 10.1183/13993003.congress-2016.PA3571

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Introducing the Homburg lung: Efficacy and safety of a minimal-invasive system for extracorporeal CO2 removal
Frederik Seiler, Franziska Trudzinski, Annegret Kamp, Konstantinos Tsitouras, Oliver Linn, Carlos Metz, Philip Böhmer, Ralf Kaiser, Sebastian Fähndrich, Heinrike Wilkens, Hendrik Haake, Robert Bals, Philipp Lepper
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3571; DOI: 10.1183/13993003.congress-2016.PA3571
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