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CPAP impact on memory processes in OSA patients, a randomized sham controlled trial

Jean-Louis Pepin, Marie Joyeux-Faure, Bernadette Naegele, Renaud Tamisier, Patrick Levy, Sandrine Launois
European Respiratory Journal 2016 48: PA3422; DOI: 10.1183/13993003.congress-2016.PA3422
Jean-Louis Pepin
1HP2 unit, Inserm unit U1042, Grenoble Alpes University, Grenoble, France
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Marie Joyeux-Faure
1HP2 unit, Inserm unit U1042, Grenoble Alpes University, Grenoble, France
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Bernadette Naegele
2Department of Physiology and Sleep, Grenoble University Hospital, Grenoble, France
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Renaud Tamisier
3Neuro-Vascular Department, Grenoble University Hospital, Grenoble, France
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Patrick Levy
4Inserm unit U836, Grenoble Neurosciences Institut, Grenoble, France
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Sandrine Launois
1HP2 unit, Inserm unit U1042, Grenoble Alpes University, Grenoble, France
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Abstract

Introduction: Patients with obstructive sleep apnea (OSA) exhibit cognitive dysfunctions such as significant memory impairment affecting the 3 episodic, procedural, and working memory systems. The objective of this study was to investigate the change in memory processes after continuous positive airway pressure (CPAP) treatment in OSA patients.

Design and methods: In this randomized, double blinded, parallel groups and sham-controlled trial, 36 patients with OSA (AHI > 15/h) and naive of CPAP treatment were randomized to receive either CPAP (n=18) or sham-CPAP (n=18) for 6-week. Three separate memory systems (verbal episodic, procedural and working memories) were evaluated for all patients, before and after treatment.

Results: Key demographics for the study population were: age 55 ± 11 years, 72.2% male, BMI: 29.5 ± 4.1 kg/m2, AHI: 37.1 ± 16.3 /h. Prior to treatment, memory performances of OSA patients were altered. In intention to treat analysis, mnesic deficit were not different after 6 weeks of CPAP or sham CPAP treatment: verbal episodic, procedural and working memory scores were comparable between both groups.

Conclusions: While 6 weeks of CPAP was an effective treatment for OSA in terms of reducing breathing disruption during sleep, it did not improve memory processes of OSA patientsin terms of verbal episodic memory, visual-motor and reading procedural memory, auditory and spatialworking memory, which are known to be altered in this context. These results suggest that OSA-neurocognitive relationship is complex and further investigations with longer CPAP exposures (at least 2 months) or on selective population (such as severe OSA patients) would be of interest.

  • Apnoea / Hypopnea
  • Sleep disorders
  • Copyright ©the authors 2016
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CPAP impact on memory processes in OSA patients, a randomized sham controlled trial
Jean-Louis Pepin, Marie Joyeux-Faure, Bernadette Naegele, Renaud Tamisier, Patrick Levy, Sandrine Launois
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3422; DOI: 10.1183/13993003.congress-2016.PA3422

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CPAP impact on memory processes in OSA patients, a randomized sham controlled trial
Jean-Louis Pepin, Marie Joyeux-Faure, Bernadette Naegele, Renaud Tamisier, Patrick Levy, Sandrine Launois
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3422; DOI: 10.1183/13993003.congress-2016.PA3422
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