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The impact of CPAP on circulating IGF-1 in patients with OSAS

Andreas Palm, Christian Berne, Helena Igelström, Pernilla Åsenlöv, Christer Janson, Eva Lindberg
European Respiratory Journal 2016 48: PA3421; DOI: 10.1183/13993003.congress-2016.PA3421
Andreas Palm
1Department of Medical Sciences, Uppsala University, Allergy and Sleep Research, Uppsala, Sweden
2Centre for Research and Development, County Council of Gävleborg, Gavle, Sweden
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Christian Berne
3Department of Medical Sciences, Uppsala University, Clinical Diabetology and Metabolism, Uppsala, Sweden
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Helena Igelström
4Department of Neuroscience, Uppsala University, Section of Physiotherapy, Uppsala, Sweden
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Pernilla Åsenlöv
4Department of Neuroscience, Uppsala University, Section of Physiotherapy, Uppsala, Sweden
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Christer Janson
1Department of Medical Sciences, Uppsala University, Allergy and Sleep Research, Uppsala, Sweden
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Eva Lindberg
1Department of Medical Sciences, Uppsala University, Allergy and Sleep Research, Uppsala, Sweden
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Abstract

Background: Obstructive sleep apnea syndrome (OSAS) is a disease with metabolic consequences and is associated with decreased levels of insulin-like growth factor-1 (IGF-1).

Aim: To investigate whether continuous positive airway pressure (CPAP) increase IGF-1 in patients with OSAS.

Methods: Consecutive patients with OSAS were recruited from a sleep clinic and IGF-1 was measured before initiation of CPAP and at follow-up after 4.8±2.4 months. Patients compliant to CPAP treatment (usage >4 hours/night) were compared with those considered to be non-compliant (usage <4 hours/night).

Results: Complete data were obtained from 70 subjects (men 85.7%, age 55.8±11.9 years, apnea-hypopnea index (AHI) 42.5±21.1, Epworth sleepiness scale (ESS) 12.2±4.5). In those compliant to CPAP (n=41), there was an increase in IGF-1 with 22.1±25.3 ng/ml compared to 2.3±23.4 ng/ml in the non-compliant group (n=29) (P=0.0014). In multivariate analysis adjusting for gender, age, body mass index (BMI), average saturation during the night recording and AHI, there was a correlation between an increase in IGF-1 levels and compliance to CPAP (β-coefficient 27.4; 95% CI: 15.4-39.4), change in BMI (β-coefficient -6.8; 95% CI: -11.1- -2.6) and change in HbA1c (β-coefficient -1.7; 95 CI: -3.3- -0.06).

Conclusion: CPAP >4 hours/night increases serum levels of IGF-1 in patients with OSAS.

  • Sleep disorders
  • Apnoea / Hypopnea
  • Adolescents
  • Copyright ©the authors 2016
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The impact of CPAP on circulating IGF-1 in patients with OSAS
Andreas Palm, Christian Berne, Helena Igelström, Pernilla Åsenlöv, Christer Janson, Eva Lindberg
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3421; DOI: 10.1183/13993003.congress-2016.PA3421

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The impact of CPAP on circulating IGF-1 in patients with OSAS
Andreas Palm, Christian Berne, Helena Igelström, Pernilla Åsenlöv, Christer Janson, Eva Lindberg
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3421; DOI: 10.1183/13993003.congress-2016.PA3421
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More in this TOC Section

  • Telehealthcare interventions in the management of obstructive sleep apnoea hypopnoea syndrome (OSAHS) in continuous positive airway pressure (CPAP) users - A systematic review
  • Comparison of peri-pharyngeal muscle recruitment during upper airway obstruction in patients with OSA and healthy subjects during wakefulness and sleep
  • Persistent daytime hypercapnia predicts poor prognosis in OSAS undergoing CPAP therapy
Show more 4.2 Sleep and Control of Breathing

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