Abstract
Background: Obstructive sleep apnea syndrome (OSAS) is a disease with metabolic consequences and is associated with decreased levels of insulin-like growth factor-1 (IGF-1).
Aim: To investigate whether continuous positive airway pressure (CPAP) increase IGF-1 in patients with OSAS.
Methods: Consecutive patients with OSAS were recruited from a sleep clinic and IGF-1 was measured before initiation of CPAP and at follow-up after 4.8±2.4 months. Patients compliant to CPAP treatment (usage >4 hours/night) were compared with those considered to be non-compliant (usage <4 hours/night).
Results: Complete data were obtained from 70 subjects (men 85.7%, age 55.8±11.9 years, apnea-hypopnea index (AHI) 42.5±21.1, Epworth sleepiness scale (ESS) 12.2±4.5). In those compliant to CPAP (n=41), there was an increase in IGF-1 with 22.1±25.3 ng/ml compared to 2.3±23.4 ng/ml in the non-compliant group (n=29) (P=0.0014). In multivariate analysis adjusting for gender, age, body mass index (BMI), average saturation during the night recording and AHI, there was a correlation between an increase in IGF-1 levels and compliance to CPAP (β-coefficient 27.4; 95% CI: 15.4-39.4), change in BMI (β-coefficient -6.8; 95% CI: -11.1- -2.6) and change in HbA1c (β-coefficient -1.7; 95 CI: -3.3- -0.06).
Conclusion: CPAP >4 hours/night increases serum levels of IGF-1 in patients with OSAS.
- Copyright ©the authors 2016
