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Effective patient selection for PCD diagnostics; the PICADAR score with nasal nitric oxide

Samuel Collins, Laura Behan, Kerry Gove, Amanda-Lea Harris, Jane Lucas
European Respiratory Journal 2016 48: PA3124; DOI: 10.1183/13993003.congress-2016.PA3124
Samuel Collins
1Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
2Clinical and Experimental Sciences Academic Unit, University of Southampton, Southampton, United Kingdom
3NIHR Southampton Respiratory Biomedical Research Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
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Laura Behan
1Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
2Clinical and Experimental Sciences Academic Unit, University of Southampton, Southampton, United Kingdom
3NIHR Southampton Respiratory Biomedical Research Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
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Kerry Gove
1Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
3NIHR Southampton Respiratory Biomedical Research Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
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Amanda-Lea Harris
2Clinical and Experimental Sciences Academic Unit, University of Southampton, Southampton, United Kingdom
3NIHR Southampton Respiratory Biomedical Research Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
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Jane Lucas
1Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
2Clinical and Experimental Sciences Academic Unit, University of Southampton, Southampton, United Kingdom
3NIHR Southampton Respiratory Biomedical Research Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
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Tables

  • Accuracy of individual/combination testing using PICADAR and nasal nitric oxide (nNO)

    Accuracy of single test (nNO or PICADAR)Accuracy of simultaneous testing (nNO or PICADAR positive)
    nNO (30nl/min)nNo (77nl/min)nNo (100nl/min)PICADARnNO (30nl/min) + PICADARnNO (77nl/min) + PICADARnNO (100nl/min) + PICADAR
    True pos30313329313133
    True neg1059181105998678
    False pos620306122533
    False neg3204220
    Sens.(95% CI)0.91 (0.76-0.98)0.94 (0.80-0.99)1.00 (0.89-1.00)0.88 (0.72-0.97)0.94 (0.80-0.99)0.94 (0.80-0.99)1.00 (0.89-1.0)
    Spec.(95% CI)0.95 (0.89-0.98)0.82 (0.74-0.89)0.73 (0.64-0.81)0.95 (0.89-0.98)0.89 (0.82-0.94)0.78 (0.69-0.85)0.70 (0.60-0.79)
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Effective patient selection for PCD diagnostics; the PICADAR score with nasal nitric oxide
Samuel Collins, Laura Behan, Kerry Gove, Amanda-Lea Harris, Jane Lucas
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3124; DOI: 10.1183/13993003.congress-2016.PA3124

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Effective patient selection for PCD diagnostics; the PICADAR score with nasal nitric oxide
Samuel Collins, Laura Behan, Kerry Gove, Amanda-Lea Harris, Jane Lucas
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3124; DOI: 10.1183/13993003.congress-2016.PA3124
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