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The efficacy of high-flow nasal cannulae oxygen therapy in severe acute exacerbation of chronic obstructive pulmonary disease: A randomized controlled trial

Myoung Kyu Lee, Sang-Ha Kim, Won-Yeon Lee, Suk Joong Yong, Seok Jeong Lee, Ye-Ryung Jung
European Respiratory Journal 2016 48: PA3058; DOI: 10.1183/13993003.congress-2016.PA3058
Myoung Kyu Lee
1Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
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Sang-Ha Kim
1Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
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Won-Yeon Lee
1Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
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Suk Joong Yong
1Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
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Seok Jeong Lee
1Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
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Ye-Ryung Jung
1Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
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Abstract

High flow nasal cannulae (HFNC) oxygen therapy has demonstrated an effect comparable with non-invasive ventilation (NIV). We conducted the prospective randomized controlled study to compare the effectiveness between the HFNC and NIV in severe AECOPD with moderate hypercapnic acute respiratory failure.

We enrolled the patients who hospitalized with severe AECOPD from January 2013 to February 2015. Each group of eligible patients received HFNC or NIV oxygen therapy respectively. The primary end point was the 30-day mortality. Treatment failure was defined that the patients underwent intubation with mechanical ventilation due to continuous hypoxia and hypercapnia despite of HFNC or NIV.

Finally 68 patients underwent randomization. The mean age was 72.4 ± 9.5 years. The 30-day mortality was 22.2% on HFNC and 28.1% on NIV group, and treatment failure was 33.3% on HFNC and 50.0% on NIV groups, respectively. Hypercapnia was more improved in HFNC oxygen therapy group than NIV group in severe AECOPD with respiratory failure HFNC oxygen therapy may be alternative to NIV therapy in severe AECOPD.

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  • COPD - exacerbations
  • Non-invasive ventilation - acute respiratory failure
  • Oxygen therapy
  • Copyright ©the authors 2016
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The efficacy of high-flow nasal cannulae oxygen therapy in severe acute exacerbation of chronic obstructive pulmonary disease: A randomized controlled trial
Myoung Kyu Lee, Sang-Ha Kim, Won-Yeon Lee, Suk Joong Yong, Seok Jeong Lee, Ye-Ryung Jung
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3058; DOI: 10.1183/13993003.congress-2016.PA3058

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The efficacy of high-flow nasal cannulae oxygen therapy in severe acute exacerbation of chronic obstructive pulmonary disease: A randomized controlled trial
Myoung Kyu Lee, Sang-Ha Kim, Won-Yeon Lee, Suk Joong Yong, Seok Jeong Lee, Ye-Ryung Jung
European Respiratory Journal Sep 2016, 48 (suppl 60) PA3058; DOI: 10.1183/13993003.congress-2016.PA3058
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More in this TOC Section

  • Outcome of non-invasive domiciliary ventilation in elderly patients
  • Chronic obstructive pulmonary disease admitted to an intensive care unit because of acute respiratory failure: How do severity of acidosis effect short and long term mortality?
  • Outcome of high-flow nasal cannula for acute hypoxemic respiratory failure due to pneumocystis pneumonia
Show more 2.2 Noninvasive Ventilatory Support

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