Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions

Markers of cellular immunity in the diagnosis of tuberculosis pleurisy

Viacheslav Zhuravlev, Marina Dyakova, Dilyara Esmedlyaeva, Tatiana Perova
European Respiratory Journal 2016 48: PA2711; DOI: 10.1183/13993003.congress-2016.PA2711
Viacheslav Zhuravlev
1Department of Laboratory Diagnostics, Research Institute of the Phthisiopulmonology, St. Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marina Dyakova
1Department of Laboratory Diagnostics, Research Institute of the Phthisiopulmonology, St. Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dilyara Esmedlyaeva
1Department of Laboratory Diagnostics, Research Institute of the Phthisiopulmonology, St. Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tatiana Perova
1Department of Laboratory Diagnostics, Research Institute of the Phthisiopulmonology, St. Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

In recent years, for the early diagnosis of tuberculosis pleurisy (TP) most widely studies of cellular immunity markers adenosine deaminase (ADA) and interferon-gamma (INF-γ). The growth of the ADA activity in pleural effusionis due to the increase of isoenzyme ADA-2. The data about diagnostic value another marker of cell-mediated immunity - neopterin (Np), as and about ADA-2 are few and controversy.

Objective: to compare the diagnostic efficiency of the ADA, ADA-2, INF-γ, Np in the definition of the specific nature of pleurisy.

Materials: to study 102 patients with pleural effusion, including 70 with clinically diagnosed TP. ADA and ADA-2 activity were measured by colorimetric method, INF-γ, Np level – with ELISA.

Results: ADA, ADA-2 activity and INF-γ production, but not Np level, were significantly higher in patients with TP than in non-TP. The following optimal cut-off values were used: for ADA – 35 U/l, for ADA-2 – 20 U/l, for INF-γ – 180 pg/ml, for Np – 13 nmol/l. The diagnostic sensitivity, specifity and diagnostic accuracy of ADA were 95,5%, 93% and 95%, of ADA-2 – 94%, 93% and 92%, of INF-γ – 91%, 96% and 93%, of Np – 45%, 83% and 56%. Only in TP group ADA, ADA-2 and IFN-γ levels were strongly correlated. The correlation coefficient was 0,77 for ADA and ADA-2, 0,35 for ADA and IFN-γ and 0,55 for ADA-2 and IFN-γ (p<0,01 for all).

Conclusion: ADA, ADA-2 and INF-γ could be used with a similar efficacy for the differential diagnostics of TP. Despite the fact that the Np level is less informative, however, this marker can be useful for monitoring diseases associated with the activation of cell-mediated immune response.

  • Tuberculosis - diagnosis
  • Biomarkers
  • Immunology
  • Copyright ©the authors 2016
Previous
Back to top
Vol 48 Issue suppl 60 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Markers of cellular immunity in the diagnosis of tuberculosis pleurisy
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Markers of cellular immunity in the diagnosis of tuberculosis pleurisy
Viacheslav Zhuravlev, Marina Dyakova, Dilyara Esmedlyaeva, Tatiana Perova
European Respiratory Journal Sep 2016, 48 (suppl 60) PA2711; DOI: 10.1183/13993003.congress-2016.PA2711

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Markers of cellular immunity in the diagnosis of tuberculosis pleurisy
Viacheslav Zhuravlev, Marina Dyakova, Dilyara Esmedlyaeva, Tatiana Perova
European Respiratory Journal Sep 2016, 48 (suppl 60) PA2711; DOI: 10.1183/13993003.congress-2016.PA2711
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Does every necrotizing granulomatous inflammation at NSCLC resection materials require treatment?
  • Evaluation of pulmonary TB treatment efficiency depending on polymorphism of glutathione-S-transferasexenobiotic biotransformation enzyme and on sensitivity profile
  • Effect of treatment of drug resistant tuberculosis on thyroid stimulating hormone
Show more 10.2 Tuberculosis

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society