Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Assessment of anti-tuberculosis activity of extracts of cinnamomum verum and solanun surattense along with isoniazid

Shashikant Vaidya, Jaishankar Sharma, Jinesh Maniar, Nikita Prabhu, Mubina Mamawala, Suvarna Joshi-Pundit, Abhay Chowdhary
European Respiratory Journal 2016 48: PA2691; DOI: 10.1183/13993003.congress-2016.PA2691
Shashikant Vaidya
1Department of Clinical Pathology, Haffkine Institute for Training, Research and Testing, Mumbai, MaharashtraIndia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jaishankar Sharma
1Department of Clinical Pathology, Haffkine Institute for Training, Research and Testing, Mumbai, MaharashtraIndia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jinesh Maniar
1Department of Clinical Pathology, Haffkine Institute for Training, Research and Testing, Mumbai, MaharashtraIndia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nikita Prabhu
1Department of Clinical Pathology, Haffkine Institute for Training, Research and Testing, Mumbai, MaharashtraIndia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mubina Mamawala
1Department of Clinical Pathology, Haffkine Institute for Training, Research and Testing, Mumbai, MaharashtraIndia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Suvarna Joshi-Pundit
1Department of Clinical Pathology, Haffkine Institute for Training, Research and Testing, Mumbai, MaharashtraIndia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Abhay Chowdhary
2Department of Microbiology, Grant Medical College and J.J. Group of Hospitals, Mumbai, MaharashtraIndia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Introduction: Tuberculosis(TB) remains a leading cause of mortality worldwide.Drug resistant TB have increased need for developing novel antituberculosis agents,using medicinal plants.

Aims and objectives: Study assessed antituberculosis and combined activity with Isoniazide(INH) of extracts of Cinnamomum verum & Solanum surattense against Mycobacterium tuberculosis H37Rv strain.

Methods: Aqueous & methanolic extracts was prepared by soxhet extraction and their phytochemical screening was done. Median Cytotoxicity (CC50) was estimated by MTT assay using cell line. Antituberculosis activity of extracts was tested by agar dilution & Microscopic Observation of Drug Susceptibility Assay (MODS).50% inhibition (IC50) was calculated by Resazurine Microtitre Assay (REMA).The combined effect of the extracts with INH was evaluated by checkerboard titrations.

Results: Phytochemical analysis showed flavanoids, tannins,steroids & essential-oils in both extracts. Minimum Inhibitory Concentration(MIC) of aqueous & methanolic extracts of both plants showed 10 mcg/ml by agar dilution method.Acquous (CAS) & methanolic(CMS) extracts of Cinnamomum showed MIC value of 0.5 & 2 mcg/ ml respectively, while aqueous (KAS) & methanolic (KMS) extracts of Solanum showed MIC value of 2 & 1 mcg/ ml resp. by MODS. IC 50 of CAS & CMS was 7.961 & 4.016 mcg/ ml respectively while IC50 of KAS & KMS was 11.27 & 8.5 mcg/ ml resp. by REMA. Antagonistic activity was observed in both plant extracts with INH.

Conclusion: Study demonstrated antituberculosis activity of plants,though antagonistic activity with INH.Active components in extracts need to be evaluated & standard testing protocol to be developed.

  • Tuberculosis - management
  • MDR-TB
  • Treatments
  • Copyright ©the authors 2016
Previous
Back to top
Vol 48 Issue suppl 60 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Assessment of anti-tuberculosis activity of extracts of cinnamomum verum and solanun surattense along with isoniazid
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Assessment of anti-tuberculosis activity of extracts of cinnamomum verum and solanun surattense along with isoniazid
Shashikant Vaidya, Jaishankar Sharma, Jinesh Maniar, Nikita Prabhu, Mubina Mamawala, Suvarna Joshi-Pundit, Abhay Chowdhary
European Respiratory Journal Sep 2016, 48 (suppl 60) PA2691; DOI: 10.1183/13993003.congress-2016.PA2691

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Assessment of anti-tuberculosis activity of extracts of cinnamomum verum and solanun surattense along with isoniazid
Shashikant Vaidya, Jaishankar Sharma, Jinesh Maniar, Nikita Prabhu, Mubina Mamawala, Suvarna Joshi-Pundit, Abhay Chowdhary
European Respiratory Journal Sep 2016, 48 (suppl 60) PA2691; DOI: 10.1183/13993003.congress-2016.PA2691
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Diagnostic accuracy of pleural fluid adenosine deaminase in patients with tuberculous pleural effusion while keeping pleural biopsy as a gold standard
  • Features of different M.tuberculosis strains that were isolated from MDR-TB patients in Kharkiv, Ukraine
  • GENE-XPERT gives early diagnosis in early tuberculosis
Show more 10.2 Tuberculosis

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society