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Compared efficacies of lung delivery using two nebulizers in the prophylaxis against pneumocystis carinii pneumonia

Audag Nicolas, Liistro Giuseppe, Leal Teresinha, Reychler Gregory
European Respiratory Journal 2016 48: PA2649; DOI: 10.1183/13993003.congress-2016.PA2649
Audag Nicolas
1Service de Médecine Physique et Réadaptation, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium
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Liistro Giuseppe
2Service de Pneumologie, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium
3Institut de Recherche Expérimentale et Clinique (IREC), Pôle de Pneumologie, ORL & Dermatologie, Université Catholique de Louvain, Bruxelles, Belgium
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Leal Teresinha
4Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Bruxelles, Belgium
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Reychler Gregory
1Service de Médecine Physique et Réadaptation, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium
2Service de Pneumologie, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium
3Institut de Recherche Expérimentale et Clinique (IREC), Pôle de Pneumologie, ORL & Dermatologie, Université Catholique de Louvain, Bruxelles, Belgium
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Abstract

INTRODUCTION: Nebulized pentamidine is commonly used to prevent Pneumocystis carinii pneumonia in immunosuppressed patients. A specifically designed nebulizer is required to ensure deep lung deposition. The Respirgard II® is currently used as the reference device for pentamidine nebulization. However, all nebulizers with comparable properties could be used for the purpose.

AIMS AND OBJECTIVES: This in vivo study aims at comparing the efficacy of lung delivery using a new nebulizer (ISO-NEB®) to that of the reference nebulizer.

METHODS: The study was conducted in 5 healthy subjects. Amikacin (500mg/4 mL) was nebulized during a single session of 10 minutes using either the ISO-NEB® or the Respirgard II® device. A wash-out period of one week was observed between both nebulizations. Urine was collected for 24 hours following nebulization. Total daily amounts of amikacin excreted in the urine (Cu max) were assesed and the elimination constants were calculated.

RESULTS: No difference in lung delivery dose was observed: the total daily amount of amikacin excreted in the urine (3.5% vs. 3.6%, p=0.893) and the elimination constant (0.159 vs. 0.130, p=0.225) were similar in the two tested devices.

CONCLUSION: Respirgard II® and ISO-NEB® have similar in vivo efficacies. ISO-NEB® can thus be considered a valuable alternative to the currently recommended nebulizer.

  • Pneumonia
  • Immunosuppression
  • Physiotherapy care
  • Copyright ©the authors 2016
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Compared efficacies of lung delivery using two nebulizers in the prophylaxis against pneumocystis carinii pneumonia
Audag Nicolas, Liistro Giuseppe, Leal Teresinha, Reychler Gregory
European Respiratory Journal Sep 2016, 48 (suppl 60) PA2649; DOI: 10.1183/13993003.congress-2016.PA2649

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Compared efficacies of lung delivery using two nebulizers in the prophylaxis against pneumocystis carinii pneumonia
Audag Nicolas, Liistro Giuseppe, Leal Teresinha, Reychler Gregory
European Respiratory Journal Sep 2016, 48 (suppl 60) PA2649; DOI: 10.1183/13993003.congress-2016.PA2649
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