Abstract
The aim of study was to evaluate the current level of hospital-acquired pneumonia(HAP)/ventilator-associated pneumonia(VAP) treatment in adults intensive care units (ICUs) in Korea with the epidemiology of multidrug-resistant (MDR) pathogens. A prospective, multicenter, observational study was conducted in six tertiary referral hospitals from August 2012 to June 2015. Total 356 patients were included with 249 males. Mean age was 67 years. Pathogens were found in 205 (59%) patients, and Acinetobacter baumanii was the most common pathogen (38%) followed by Staphylococcus aureus (24%). The MDR bacteria were isolated in 139 patients. Carbapenem-resistant Acinetobacter baumanii was the most common MDR pathogen (38%). As empirical antibiotics of HAP/VAP, extended-spectrum penicillin/β-lactamase inhibitor was initially used the most (39%). The 28-day and in-hospital mortality of patients was 31% and 48%, respectively. This study showed that the in-hospital mortality of HAP/VAP patients was high, whereas, there was a discrepancy between the common MDR pathogens and the choice of empirical antibiotics in adults ICUs in Korea.
- Copyright ©the authors 2016
