Abstract
Background: Exacerbations are a major cause of treatment of COPD patients for medical care. The ground for the appointment of antibacterial drugs for these patients is the leading role of bacterial factor.We aimed to study bacterial landscape and antibiotic susceptibility of sputum from patients with exacerbation of COPD.
Materials and Methods: The microbiologic screening results of sputum 531 patients with exacerbation of COPD hospitalized at National Scientific Medical Center during 2004-2013 were prospectively analyzed.
Results: A total of 1210 isolates from these patients were included to the study. The most frequently pathogens were Streptococcus pneumoniae (27.9%) and Moraxella catarrhalis (20.1%). The prevalence of S.pneumoniae was increased from 18.1% in 2004 to 53.5% in 2013 (p<0.001). However, in should be noted decrease the detection rate of M.catarrhalis from 26.7% to 10.7% (p<0.001) respectively. Also were found S.aureus - 3,8%, P.aeruginosa - 2,1%, St,pyogenes - 7,9% Enterobacteriaceae - 3,5% of the total number of isolates. Study results showed a dynamic of decreasing antibiotic susceptibility of St.pneumoniae: to penicillin from 89.4% in 2004 to 46.1% in 2013 (p<0.001), to ceftiaxone from 96.4% to 69.5% (p<0.01), to cefotaxime from90.6% to 55.5% (p<0.02), to levofloxacin from 100% to 64% (p<0.001), and ciprofloxacin from 72% to 41.6% (p<0.05) respectively.
Conclusion: Constant microbiologic screening of patients with exacerbation of COPD, necessary to control the possible change of pathogens, as well as their level of antibiotic resistance. This leads to follow a strict policy on the use of antibiotics, which should be based on local data.
- Copyright ©the authors 2016
