Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions

Impact of nasopharyngeal pneumococcal colonization on dendritic cell-dependent protective immunity against invasive pneumococcal disease in mice

Anne Dommaschk, Nadine Ding, Lara Friederike Bittersohl, Gabriele Kirchhof, Tobias Welte, Ulrich A. Maus
European Respiratory Journal 2016 48: PA2592; DOI: 10.1183/13993003.congress-2016.PA2592
Anne Dommaschk
1Experimental Pneumology, Hannover Medical School, Hannover, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nadine Ding
1Experimental Pneumology, Hannover Medical School, Hannover, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lara Friederike Bittersohl
1Experimental Pneumology, Hannover Medical School, Hannover, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gabriele Kirchhof
1Experimental Pneumology, Hannover Medical School, Hannover, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tobias Welte
2Clinic for Pneumology, Hannover Medical School, Hannover, Germany
3BREATH, German Center for Lung Research, Hannover, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ulrich A. Maus
1Experimental Pneumology, Hannover Medical School, Hannover, Germany
3BREATH, German Center for Lung Research, Hannover, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Nasopharyngeal colonization with Streptococcus pneumoniae (Spn) is an essential precondition to develop pneumococcal pneumonia. At the same time, it has also been shown to mount adaptive immune responses against Spn in mice and humans. Until now, the cellular response of the nasopharyngeal compartment, including the nasal-associated lymphoid tissue (NALT), to pneumococcal colonization and its importance for developing adaptive immune responses is poorly defined. We here show that single and even more so repetitive nasopharyngeal colonization triggered Spn-specific antibody responses in mice conferring protection against invasive pneumococcal disease (IPD). Repetitively colonized mice responded with substantial expansion of the dendritic cell (DC) compartment in nasopharyngeal tissue and NALT, along with elevated PspA-specific IgA, IgG1 and IgG2a antibody titers in plasma as well as nasal wash fluids and nasopharyngeal tissue supernatants. Relative to WT mice, both Diphtheria toxin- induced depletion of DCs in previously colonized chimeric zDC+/DTR mice and colonization of Flt3LKO mice led to significantly diminished antibody titers, as well as impaired protective immunity against IPD. Collectively, the data reveal a central role for DCs of the nasopharyngeal compartment to mediate anti-pneumococcal mucosal immune responses after colonization with Spn and hence protection against IPD in mice. These data may contribute to improve our understanding of the highly specialized nasopharyngeal/NALT compartment to expand the application of novel nasopharyngeal vaccination strategies against pneumococcal diseases in humans.

  • Immunology
  • Infections
  • Lung injury
  • Copyright ©the authors 2016
Previous
Back to top
Vol 48 Issue suppl 60 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Impact of nasopharyngeal pneumococcal colonization on dendritic cell-dependent protective immunity against invasive pneumococcal disease in mice
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Impact of nasopharyngeal pneumococcal colonization on dendritic cell-dependent protective immunity against invasive pneumococcal disease in mice
Anne Dommaschk, Nadine Ding, Lara Friederike Bittersohl, Gabriele Kirchhof, Tobias Welte, Ulrich A. Maus
European Respiratory Journal Sep 2016, 48 (suppl 60) PA2592; DOI: 10.1183/13993003.congress-2016.PA2592

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Impact of nasopharyngeal pneumococcal colonization on dendritic cell-dependent protective immunity against invasive pneumococcal disease in mice
Anne Dommaschk, Nadine Ding, Lara Friederike Bittersohl, Gabriele Kirchhof, Tobias Welte, Ulrich A. Maus
European Respiratory Journal Sep 2016, 48 (suppl 60) PA2592; DOI: 10.1183/13993003.congress-2016.PA2592
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • The effect of coding on community acquired pneumonia reported mortality
  • Community-acquired pneumonia requiring hospitalization in HIV-infected patients
  • Community acquired pneumonia and co-existing acute kidney injury have poor clinical outcomes
Show more 10.1 Respiratory Infections

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2021 by the European Respiratory Society