Abstract
Introduction: In the last two decades noninvasive ventilation (NIV) has become an integral part of the protocol for the treatment of patients with acute respiratory failure.
Aim: To define the factors that lead to failure of treatment with NIV, in order to avoid the delay of treatment with invasive mechanical ventilation, thus enabling better clinical management of the affected patients.
Methods: Retrospectively were analyzed 120 patients with type 2 chronic respiratory failure due to COPD exacerbation, treated with NIV. The following data were analyzed: demographics, laboratory data, Acute Physiology and Chronic Health Evaluation (APACHE) II score; respiratory rate; pH; pO2; pCO2. Acid-base status was evaluated at the beginning and 1 hour after NIV treatment.
Results: On admission arterial pH levels were lower (p<0.05) and APACHE II score and pCO2 were higher (p<0.05) in the NIV failure group. Arterial pH was lower (p<0.05) and pCO2 and respiratory rate were higher (p<0.05) after 1 hour in the NIV failure group. Age showed no correlation with the success of NIV treatment.
Conclusion: Patients with higher pH and lower pCO2 and APACHE II score at admission, and by improving of these parameters after 1 hour have better outcome from treatment with NIV.
- Copyright ©the authors 2016