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Influence of single nucleotide polymorphisms in post-bronchiolitis wheezing

Alfonso E. Alvarez, Fernando A.L. Marson, Carmem S. Bertuzzo, Juliana C.S. Santiago, Emilio C.E. Baracat, Antonia T. Tresoldi, Mariana T.N. Romaneli, Patricia G. Schlodtmann, Ester Correa, Celize C.B. Almeida, Therezinha Oliveira, Maria Luisa F. Miranda, Marcelo C. Reis, Jose Vicente De Pieri, Clarisse W. Arns, Jose Dirceu Ribeiro
European Respiratory Journal 2016 48: PA1599; DOI: 10.1183/13993003.congress-2016.PA1599
Alfonso E. Alvarez
1Department of Pediatrics, State University of Campinas, Campinas, SPBrazil
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Fernando A.L. Marson
2Department of Medical Genetics, State University of Campinas, Campinas, SPBrazil
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Carmem S. Bertuzzo
2Department of Medical Genetics, State University of Campinas, Campinas, SPBrazil
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Juliana C.S. Santiago
3Biological Institute, State University of Campinas, Campinas, SPBrazil
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Emilio C.E. Baracat
4Department of Pediatrics, Clinical Hospital of Sumare - State University of Campinas, Sumare, SPBrazil
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Antonia T. Tresoldi
1Department of Pediatrics, State University of Campinas, Campinas, SPBrazil
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Mariana T.N. Romaneli
1Department of Pediatrics, State University of Campinas, Campinas, SPBrazil
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Patricia G. Schlodtmann
5Department of Pediatrics, Vera Cruz Hospital, Campinas, SPBrazil
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Ester Correa
5Department of Pediatrics, Vera Cruz Hospital, Campinas, SPBrazil
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Celize C.B. Almeida
1Department of Pediatrics, State University of Campinas, Campinas, SPBrazil
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Therezinha Oliveira
1Department of Pediatrics, State University of Campinas, Campinas, SPBrazil
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Maria Luisa F. Miranda
4Department of Pediatrics, Clinical Hospital of Sumare - State University of Campinas, Sumare, SPBrazil
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Marcelo C. Reis
4Department of Pediatrics, Clinical Hospital of Sumare - State University of Campinas, Sumare, SPBrazil
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Jose Vicente De Pieri
5Department of Pediatrics, Vera Cruz Hospital, Campinas, SPBrazil
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Clarisse W. Arns
3Biological Institute, State University of Campinas, Campinas, SPBrazil
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Jose Dirceu Ribeiro
1Department of Pediatrics, State University of Campinas, Campinas, SPBrazil
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Abstract

INTRODUCTION: a large number of infants present post-bronchiolitis wheezing. It is not clear if genetics factors contribute to it.

AIMS: To evaluate the influence of Single Nucleotide Polymorphisms (SNP) in long-term outcomes of patients hospitalized for bronchiolitis.

METHODS: All patients hospitalized for bronchiolitis in two winter seasons in 3 tertiary pediatric hospitals were evaluated for epidemiological variables, underwent nasopharyngeal aspirate for detection of virus by PCR technique and blood collection to identify presence of SNPs. Polymorphisms were screened by AccuFill™ System for the OpenArray® Real-Time PCR Platform. Studied SNPs (gene) were: rs4986790 (TLR4), rs4986791 (TLR4), rs1927911 (TLR4), rs898830 (TLR2), rs7656411 (TLR2), rs352162 (TLR9), rs187084 (TLR9), rs1065341 (CCL5), rs2107538 (CCL5), rs2280788 (CCL5), rs2280789 (CCL5), rs10757212 (IFNA5), rs1060826 (NOS2), rs11688 (JUN), rs10735810 (VDR) and rs2228570 (VDR). All patients were followed-up for one year.

RESULTS: 85 patients (all < 1 year) were followed-up. Outcomes after 3 and 12 months of discharge (in percentage) were: wheezing (58.8 and 46.1), use of bronchodilators (56.0 and 47.4), use of oral steroids (38.8 and 43.4), need to seek the emergency room (38.1 and 35.1), need of hospitalization (8.3 and 6.4), pneumonia (10.6 and 3.8). 36.5% and 11.8% of patients used inhaled steroids and montelukast, respectively. SNPs associated with worse outcome were: rs1927911 (TLR4), rs7656411 (TLR2), rs352162 (TLR9), rs187084 (TLR9), rs1060826 (NOS2), rs2280789 (CCL5), rs2228570 (VDR) (p<0,05).

CONCLUSIONS: SNPs are associated with worse long-term outcome and maintenance of symptoms in patients hospitalized for bronchiolitis.

  • Bronchiolitis
  • Infants
  • Genetics
  • Copyright ©the authors 2016
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Influence of single nucleotide polymorphisms in post-bronchiolitis wheezing
Alfonso E. Alvarez, Fernando A.L. Marson, Carmem S. Bertuzzo, Juliana C.S. Santiago, Emilio C.E. Baracat, Antonia T. Tresoldi, Mariana T.N. Romaneli, Patricia G. Schlodtmann, Ester Correa, Celize C.B. Almeida, Therezinha Oliveira, Maria Luisa F. Miranda, Marcelo C. Reis, Jose Vicente De Pieri, Clarisse W. Arns, Jose Dirceu Ribeiro
European Respiratory Journal Sep 2016, 48 (suppl 60) PA1599; DOI: 10.1183/13993003.congress-2016.PA1599

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Influence of single nucleotide polymorphisms in post-bronchiolitis wheezing
Alfonso E. Alvarez, Fernando A.L. Marson, Carmem S. Bertuzzo, Juliana C.S. Santiago, Emilio C.E. Baracat, Antonia T. Tresoldi, Mariana T.N. Romaneli, Patricia G. Schlodtmann, Ester Correa, Celize C.B. Almeida, Therezinha Oliveira, Maria Luisa F. Miranda, Marcelo C. Reis, Jose Vicente De Pieri, Clarisse W. Arns, Jose Dirceu Ribeiro
European Respiratory Journal Sep 2016, 48 (suppl 60) PA1599; DOI: 10.1183/13993003.congress-2016.PA1599
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