Abstract
OBJECTIVES: Assess whether changes in lung function occur after allogeneic hematopoietic stem cell transplant (HSCT) and determine if there is any association between pre-transplant lung function and the appearance of respiratory complications.
MATERIAL AND METHODS: 176 pre-transplant HSCT patients were studied between July 2005 and June 2015. Respiratory function tests were performed prior to transplant. Patients who developed respiratory problems were treated and a respiratory function test was repeated every 3 months during the first year and with longer periods of time afterwards. Statistical analysis: Chi-square tests and changes measured by a comparison of averages with intrasubject measures (PAIRED T-TEST and NPAR FRIEDMAN TEST procedures within SPSS system) (p<0.05).
RESULTS: At the measure of the intrasubject change for the functional parameters, the only significant factor was a decline of the FVC and FEV1, 6 months after the transplant, compared to pre-transplant values (average 223ml and 220ml respectively p=0.04 and p=0.05). The onset of pulmonary complications showed no association with pre-transplant lung function, the type of transplant performed, nor with the type of hematologic disease. However in patients with umbilical cord transplant were more common invasive aspergillosis, infectious bronchiolitis and flu (p< 0,005).
CONCLUSION: The HSCT is followed by a decline in lung function at 6 months and frequent pulmonary complications unrelated to pre-transplant lung function.
- Copyright ©the authors 2016
