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Cardio-metabolic disorder in grandparents associated with asthma in offspring: Results from a European 3-generation analysis

Anne-Elie Carsin, Francisco Real, Xavier Basagana, Simone Accordini, Shyamali Dharmage, Vivi Schlünssen, Bryndís Benediktsdóttir, Benedicte Leynaert, Christer Janson, Jordi Sunyer, Julia Dratva, Debbie Jarvis, Cecilie Svanes
European Respiratory Journal 2016 48: PA1201; DOI: 10.1183/13993003.congress-2016.PA1201
Anne-Elie Carsin
1ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
2IMIM, Hospital del Mar Medical Research Institute, Barcelona, Spain
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Francisco Real
3Department of Clinical Science, Bergen Respiratory Research Group, University of Bergen, Bergen, Norway
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Xavier Basagana
1ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
2IMIM, Hospital del Mar Medical Research Institute, Barcelona, Spain
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Simone Accordini
15Unit of Epidemiology and Medical Statistics, Department of Public Health and Community Medicine, University of Verona, Verona, Italy
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Shyamali Dharmage
4Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Australia
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Vivi Schlünssen
9Department of Public Health, Section for Environment, Occupation and Health, Aarhus University, Aarhus, Denmark
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Bryndís Benediktsdóttir
5Faculty of Medicine, Univesrity of Iceland, Reykjavik, Iceland
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Benedicte Leynaert
12UMR 1152, Pathophysiology and Epidemiology of Respiratory Diseases, INSERM, Paris, France
13UMR 1152, University Paris Diderot Paris, Paris, France
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Christer Janson
6Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
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Jordi Sunyer
1ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
2IMIM, Hospital del Mar Medical Research Institute, Barcelona, Spain
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Julia Dratva
14Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
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Debbie Jarvis
10MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom
11Department of Respiratory Epidemiology & Public Health, Imperial College London, London, United Kingdom
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Cecilie Svanes
7Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway
8Centre for International Health, University of Bergen, Bergen, Norway
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Abstract

Background: Cardio-metabolic disorders (CMD) in grandfathers have been reported to be a risk factor for asthma in their grandchildren. No study has yet replicated this finding.

Objective: To investigate the association of CMD in grandparents and parents and asthma in offspring.

Methods: We studied asthma phenotypes across three generations using data from the third follow-up of the ECRHS study, performed in 2010-2012 in 26 centres across Europe. Through a structured interview 5153 participants answered questions about respiratory disease and CMD (hypertension, heart disease, stroke, diabetes and obesity) as well as questions about their parents and children (n=11,145).

Factors influencing children asthma were examined in multivariate logistic regression models with family nested into centre as random intercept and adjusted for grandparents and parent asthma and other potential confounders.

Results: Grandfather's CMD was associated with offspring asthma (OR=1.6, 1.2-2.1); and this was stronger among male offspring (p-interaction=0.09). The effect was stronger for asthma combined with hay fever, than for asthma alone. When cardio-metabolic factors were analysed separately, significant associations were observed for grandfathers' hypertension and heart disease, while obesity did not show consistent results. No effect of grandmother or parental CMD on offspring asthma was observed.

Conclusion: These preliminary results are similar to those observed previously in Northern-Europe. Grand-father CMD was associated with subsequent asthma in offspring independently of a family history of asthma. This may have important implications with regard to public health intervention.

  • Asthma - mechanism
  • Epidemiology
  • Environment
  • Copyright ©the authors 2016
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Cardio-metabolic disorder in grandparents associated with asthma in offspring: Results from a European 3-generation analysis
Anne-Elie Carsin, Francisco Real, Xavier Basagana, Simone Accordini, Shyamali Dharmage, Vivi Schlünssen, Bryndís Benediktsdóttir, Benedicte Leynaert, Christer Janson, Jordi Sunyer, Julia Dratva, Debbie Jarvis, Cecilie Svanes
European Respiratory Journal Sep 2016, 48 (suppl 60) PA1201; DOI: 10.1183/13993003.congress-2016.PA1201

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Cardio-metabolic disorder in grandparents associated with asthma in offspring: Results from a European 3-generation analysis
Anne-Elie Carsin, Francisco Real, Xavier Basagana, Simone Accordini, Shyamali Dharmage, Vivi Schlünssen, Bryndís Benediktsdóttir, Benedicte Leynaert, Christer Janson, Jordi Sunyer, Julia Dratva, Debbie Jarvis, Cecilie Svanes
European Respiratory Journal Sep 2016, 48 (suppl 60) PA1201; DOI: 10.1183/13993003.congress-2016.PA1201
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