Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions

Role of TRPV1 and TRPV2 gene polymorphisms in the development of airway hyperresponsiveness to osmotic stimuli in patients with asthma

Denis Naumov, Juliy Perelman, Anna Prikhodko, Victor Kolosov, Elizaveta Sheludko
European Respiratory Journal 2016 48: PA1197; DOI: 10.1183/13993003.congress-2016.PA1197
Denis Naumov
1Laboratory of Prophylaxis of Nonspecific Lung Diseases, Far Eastern Scientific Centre of Physiology and Pathology of Respiration, Blagoveshchensk, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Juliy Perelman
2Laboratory of Functional Research of Respiratory System, Far Eastern Scientific Centre of Physiology and Pathology of Respiration, Blagoveshchensk, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anna Prikhodko
2Laboratory of Functional Research of Respiratory System, Far Eastern Scientific Centre of Physiology and Pathology of Respiration, Blagoveshchensk, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Victor Kolosov
1Laboratory of Prophylaxis of Nonspecific Lung Diseases, Far Eastern Scientific Centre of Physiology and Pathology of Respiration, Blagoveshchensk, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elizaveta Sheludko
1Laboratory of Prophylaxis of Nonspecific Lung Diseases, Far Eastern Scientific Centre of Physiology and Pathology of Respiration, Blagoveshchensk, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Osmolarity of the airways being influenced by air humidity serves as an important factor affecting lung function. It has been shown that high as well as low humidity may provoke bronchoconstriction in patients with asthma. TRPV1, TRPV2 and TRPV4 cation channels are expressed in the respiratory tract and were shown to mediate responses to hyper- and hypoosmotic stimuli.

The aim of the study was to investigate the effect of Thr469Ile and Ile585Val SNPs of TRPV1 gene and c.-323A>G SNP of TRPV2 gene on hypo- and hyperosmotic airway hyperresponsiveness (AH) in asthma.

Methods: The study involved 116 patients diagnosed with mild or moderate persistent uncontrolled asthma. All subjects underwent spirometry before and after the challenge tests with inhalation of nebulized distilled water (DW), hypertonic saline (HS) and test with physical exercise (PE). FEV1 fall by 10% or more was considered as a positive response. SNPs were genotyped by PCR with RFLP analysis.

Results: AA genotype and A allele of c.-323A>G SNP were significantly associated with hypoosmotic AH. Carriers of AA genotype prevailed among the patients with the AH (69% vs 48.6%, p=0.02 for additive model). Frequency of A allele was also higher in these patients (84.5% vs 68.6%, p=0.02; OR 2.5 95%CI (1.13-5.53)). Thr469Ile SNP was found to influence AH to PE. Ile469Ile variant comprised 31% of patients with positive response and only 7% in the group without the AH (p=0.04). No SNPs were associated with hyperosmotic AH to HS.

Conclusion: TRPV1 and TRPV2 SNPs may serve as factors predisposing to the development of AH to DW and PE in patients with asthma.

The study was supported by RSF (14-25-00019).

  • Asthma - mechanism
  • Genetics
  • Lung function testing
  • Copyright ©the authors 2016
Previous
Back to top
Vol 48 Issue suppl 60 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Role of TRPV1 and TRPV2 gene polymorphisms in the development of airway hyperresponsiveness to osmotic stimuli in patients with asthma
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Role of TRPV1 and TRPV2 gene polymorphisms in the development of airway hyperresponsiveness to osmotic stimuli in patients with asthma
Denis Naumov, Juliy Perelman, Anna Prikhodko, Victor Kolosov, Elizaveta Sheludko
European Respiratory Journal Sep 2016, 48 (suppl 60) PA1197; DOI: 10.1183/13993003.congress-2016.PA1197

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Role of TRPV1 and TRPV2 gene polymorphisms in the development of airway hyperresponsiveness to osmotic stimuli in patients with asthma
Denis Naumov, Juliy Perelman, Anna Prikhodko, Victor Kolosov, Elizaveta Sheludko
European Respiratory Journal Sep 2016, 48 (suppl 60) PA1197; DOI: 10.1183/13993003.congress-2016.PA1197
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Cardio-metabolic disorder in grandparents associated with asthma in offspring: Results from a European 3-generation analysis
  • Interactions of genetic variants and DNA-M of TSLP modify the eczema risk
  • LATE-BREAKING ABSTRACT: Effects of rare SERPINA1 variants on emphysema and airtrapping in SPIROMICS
Show more 6.4 Genes and Environment

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society