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LATE-BREAKING ABSTRACT: Do mesenchymal stromal cells provide an organ-specific tissue niche? – A proteomic matrisome characterization

Sara Rolandsson Enes, Emma Åhrman, Anitha Palani, Oskar Hallgren, Leif Bjermer, Stefan Scheding, Anders Malmström, Johan Malmström, Gunilla Westergren-Thorsson
European Respiratory Journal 2016 48: OA503; DOI: 10.1183/13993003.congress-2016.OA503
Sara Rolandsson Enes
1Experimental Medical Science, Lung Biology Unit, Lund University, Lund, Sweden
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Emma Åhrman
1Experimental Medical Science, Lung Biology Unit, Lund University, Lund, Sweden
2Clinical Sciences Lund, Division of Infection Medicine, Lund University, Lund, Sweden
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Anitha Palani
3Experimental Medical Science, Matrix Biology Unit, Lund University, Lund, Sweden
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Oskar Hallgren
1Experimental Medical Science, Lung Biology Unit, Lund University, Lund, Sweden
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Leif Bjermer
4Respiratory Medicine and Allergology, Lund University and Skåne University Hospital, Lund, Sweden
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Stefan Scheding
5Lund Stem Cell Center, Lund University, Lund, Sweden
6Hematology, Skåne University Hospital, Lund, Sweden
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Anders Malmström
3Experimental Medical Science, Matrix Biology Unit, Lund University, Lund, Sweden
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Johan Malmström
2Clinical Sciences Lund, Division of Infection Medicine, Lund University, Lund, Sweden
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Gunilla Westergren-Thorsson
1Experimental Medical Science, Lung Biology Unit, Lund University, Lund, Sweden
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Abstract

Background: The mesenchymal stromal cells (MSC) are potent candidates for cell therapies, due to their immune-regulatory and regenerative properties. In most clinical trials bone marrow-derived MSC have been used, also for treatment of various pulmonary diseases. Bone marrow-derived MSC play an important role within the bone marrow, by providing and maintaining a functioning niche for the hematopoiesis. The functional role of lung-resident MSC, on the other hand, is still unknown. Exploring the proteins produced by lung-derived MSC might improve our understanding of the functional role of MSC within the lung. Therefore, we aimed to characterize the proteins produced by lung-derived MSC and to compare those findings to the proteins produced by MSC isolated from bone marrow.

Methods: Proteins within the cell-layer and the conditioned medium of MSC isolated from lung biopsies and bone marrow aspirates were characterized using mass spectrometry-based quantitative proteomics.

Results: Our results indicate that MSC isolated from lung biopsies and bone marrow aspirates are prominent producers of extracellular matrix proteins. Furthermore, these analyses revealed differences between lung- and bone marrow-derived MSC, both regarding proteins identified in the cell layer and within the conditioned medium.

Conclusions: Lung-derived MSC are prominent extracellular matrix producers, and our results indicate that lung- and bone marrow-derived MSC produce different protein profiles.

  • Cell biology
  • Proteomics
  • Thoracic oncology
  • Copyright ©the authors 2016
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LATE-BREAKING ABSTRACT: Do mesenchymal stromal cells provide an organ-specific tissue niche? – A proteomic matrisome characterization
Sara Rolandsson Enes, Emma Åhrman, Anitha Palani, Oskar Hallgren, Leif Bjermer, Stefan Scheding, Anders Malmström, Johan Malmström, Gunilla Westergren-Thorsson
European Respiratory Journal Sep 2016, 48 (suppl 60) OA503; DOI: 10.1183/13993003.congress-2016.OA503

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LATE-BREAKING ABSTRACT: Do mesenchymal stromal cells provide an organ-specific tissue niche? – A proteomic matrisome characterization
Sara Rolandsson Enes, Emma Åhrman, Anitha Palani, Oskar Hallgren, Leif Bjermer, Stefan Scheding, Anders Malmström, Johan Malmström, Gunilla Westergren-Thorsson
European Respiratory Journal Sep 2016, 48 (suppl 60) OA503; DOI: 10.1183/13993003.congress-2016.OA503
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