Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions

Contextualized assay of urinary biomarkers for the diagnosis of OSA in children

Biju Thomas, John E. Connolly, Zai Ru Cheng, Veonice Bijin Au, John C. Allen Jr, Soh Gin Tan, Meilan Lim, Qiao Ling Tan, Qixian He, Yi Ping Tan, Candice Teo, Christina Seng, Arun Pugalenthi, Anne Goh, Petrina Wong, Oon Hoe Teoh
European Respiratory Journal 2016 48: OA4555; DOI: 10.1183/13993003.congress-2016.OA4555
Biju Thomas
1Paediatric Respiratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
3Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John E. Connolly
2A*STAR, Institute of Cell and Molecular Biology, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zai Ru Cheng
1Paediatric Respiratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Veonice Bijin Au
2A*STAR, Institute of Cell and Molecular Biology, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John C. Allen Jr
3Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Soh Gin Tan
1Paediatric Respiratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Meilan Lim
1Paediatric Respiratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Qiao Ling Tan
1Paediatric Respiratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Qixian He
1Paediatric Respiratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yi Ping Tan
1Paediatric Respiratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Candice Teo
1Paediatric Respiratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christina Seng
1Paediatric Respiratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Arun Pugalenthi
1Paediatric Respiratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
3Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anne Goh
1Paediatric Respiratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
3Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Petrina Wong
1Paediatric Respiratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
3Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Oon Hoe Teoh
1Paediatric Respiratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
3Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
Loading

Abstract

Introduction There is growing interest in the use of biomarkers for the diagnosis of Obstructive Sleep Apnea (OSA).

Aims Our aim was to determine if contextualized assay of urinary biomarkers reliably distinguish Primary Snoring (PS) from OSA in children.

Methods We recruited children >2 years with snoring and suspected OSA. Subjects underwent an overnight polysomnogram (PSG). Urine samples collected before (pre-PSG) and after PSG (post-PSG), were centrifuged and stored at -80oC after adding a protease inhibitor cocktail. PSGs were scored as per the AASM 2012 scoring rules. OSA was defined as Obstructive Apnoea Hypopnoea Index (OAHI) >1 (<12 years) or >5 (>12 years). Quantitative analyses of the urinary biomarkers (Uromodulin, Orosomucoid-1 and Kallikrien-1) were done using commercially available ELISA kits.

Results 146 children (mean [SD] age = 9.0 [3.7] years, 70% males) were studied. 11 (7.6%) had PS and 135 (92.4%) had OSA. The pre-PSG urinary biomarkers were not significantly different between PS and OSA in both males and females. The gender wise post-PSG urinary biomarker concentrations in PS and OSA are given in Table 1.

PSOSA
BiomarkerMale (n=7)Female (n=4)Male (n=100)Female (n=35)
Kallikrein-1†39589 (28903-82394)46008 (22967-56953)56302 (35887-88311)70481 (38449-124313)
Orosomucoid-1§896.2 (141.4-1622)126.4 (95.3-584.4)401.2 (239.8-731)433.4 (221-646.2)
Uromodulin§3781 (3010-4544)6655 (4307-12698)5854∗ (3755-8604)7265 (4574-10412)
  • Data as median (IQR). †pg/ml/mg creatinine, §ng/ml/mg creatinine, *p<0.05 compared to PS (Male)

TABLE 1.

Conclusion Early morning urinary Uromodulin level may distinguish PS from OSA in boys. Further larger studies are required to validate this finding.

  • Sleep disorders
  • Proteomics
  • Children
  • Copyright ©the authors 2016
Previous
Back to top
Vol 48 Issue suppl 60 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Contextualized assay of urinary biomarkers for the diagnosis of OSA in children
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Contextualized assay of urinary biomarkers for the diagnosis of OSA in children
Biju Thomas, John E. Connolly, Zai Ru Cheng, Veonice Bijin Au, John C. Allen Jr, Soh Gin Tan, Meilan Lim, Qiao Ling Tan, Qixian He, Yi Ping Tan, Candice Teo, Christina Seng, Arun Pugalenthi, Anne Goh, Petrina Wong, Oon Hoe Teoh
European Respiratory Journal Sep 2016, 48 (suppl 60) OA4555; DOI: 10.1183/13993003.congress-2016.OA4555

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Contextualized assay of urinary biomarkers for the diagnosis of OSA in children
Biju Thomas, John E. Connolly, Zai Ru Cheng, Veonice Bijin Au, John C. Allen Jr, Soh Gin Tan, Meilan Lim, Qiao Ling Tan, Qixian He, Yi Ping Tan, Candice Teo, Christina Seng, Arun Pugalenthi, Anne Goh, Petrina Wong, Oon Hoe Teoh
European Respiratory Journal Sep 2016, 48 (suppl 60) OA4555; DOI: 10.1183/13993003.congress-2016.OA4555
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Figures & Data
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Respiratory complications of children with Prader-Willi syndrome
  • Sleep disordered breathing (SDB) in patients with Beckwith-Wiedemann syndrome (BWS)
  • CPAP can improve respiratory effort as measured by surface electromyogram of the diaphragm (sEMGdi) in children with sleep-disordered breathing
Show more 7.1 Paediatric Respiratory Physiology and Sleep

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2021 by the European Respiratory Society