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Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension

Carole Phan, Andrei Seferian, Alice Huertas, Ly Tu, Raphael Thuillet, Caroline Sattler, Morane Le Hiress, Yuichi Tamura, Etienne-Marie Jutant, Marie-Camille Chaumais, Stéphane Bouchet, Benjamin Manéglier, Mathieu Molimard, Philippe Rousselot, Olivier Sitbon, Gérald Simonneau, David Montani, Marc Humbert, Christophe Guignabert
European Respiratory Journal 2016 48: OA262; DOI: 10.1183/13993003.congress-2016.OA262
Carole Phan
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Andrei Seferian
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Alice Huertas
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Ly Tu
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Raphael Thuillet
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Caroline Sattler
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Morane Le Hiress
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Yuichi Tamura
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Etienne-Marie Jutant
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Marie-Camille Chaumais
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Stéphane Bouchet
4Pharmacologie, CHU de Bordeaux, Bordeaux, France
5U657, INSERM and University Bordeaux, Bordeaux, France
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Benjamin Manéglier
6Service de Biologie Médicale, Centre Hospitalier de Versailles, Le Chesnay, France
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Mathieu Molimard
4Pharmacologie, CHU de Bordeaux, Bordeaux, France
5U657, INSERM and University Bordeaux, Bordeaux, France
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Philippe Rousselot
7Service D'Hématologie et D'Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France
8Medical School, Université de Versailles-Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines, France
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Olivier Sitbon
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Gérald Simonneau
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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David Montani
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Marc Humbert
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Christophe Guignabert
1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
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Article Information

vol. 48 no. suppl 60
DOI 
https://doi.org/10.1183/13993003.congress-2016.OA262

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Published online November 8, 2016.

Copyright & Usage 
Copyright ©the authors 2016

Author Information

  1. Carole Phan1,2,3,
  2. Andrei Seferian1,2,3,
  3. Alice Huertas1,2,3,
  4. Ly Tu1,2,3,
  5. Raphael Thuillet1,2,3,
  6. Caroline Sattler1,2,3,
  7. Morane Le Hiress1,2,3,
  8. Yuichi Tamura1,2,3,
  9. Etienne-Marie Jutant1,2,3,
  10. Marie-Camille Chaumais1,2,3,
  11. Stéphane Bouchet4,5,
  12. Benjamin Manéglier6,
  13. Mathieu Molimard4,5,
  14. Philippe Rousselot7,8,
  15. Olivier Sitbon1,2,3,
  16. Gérald Simonneau1,2,3,
  17. David Montani1,2,3,
  18. Marc Humbert1,2,3 and
  19. Christophe Guignabert1,2,3
  1. 1UMR_S 999, Marie Lannelongue Hospital, INSERM, Le Plessis-Robinson, France
  2. 2Medical School, Univ. Paris-Sud et Université Paris-Saclay, Le Kremlin-Bicêtre, France
  3. 3Bicêtre Hospital, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, AP-HP, Le Kremlin-Bicêtre, France
  4. 4Pharmacologie, CHU de Bordeaux, Bordeaux, France
  5. 5U657, INSERM and University Bordeaux, Bordeaux, France
  6. 6Service de Biologie Médicale, Centre Hospitalier de Versailles, Le Chesnay, France
  7. 7Service D'Hématologie et D'Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France
  8. 8Medical School, Université de Versailles-Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines, France

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Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension
Carole Phan, Andrei Seferian, Alice Huertas, Ly Tu, Raphael Thuillet, Caroline Sattler, Morane Le Hiress, Yuichi Tamura, Etienne-Marie Jutant, Marie-Camille Chaumais, Stéphane Bouchet, Benjamin Manéglier, Mathieu Molimard, Philippe Rousselot, Olivier Sitbon, Gérald Simonneau, David Montani, Marc Humbert, Christophe Guignabert
European Respiratory Journal Sep 2016, 48 (suppl 60) OA262; DOI: 10.1183/13993003.congress-2016.OA262

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Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension
Carole Phan, Andrei Seferian, Alice Huertas, Ly Tu, Raphael Thuillet, Caroline Sattler, Morane Le Hiress, Yuichi Tamura, Etienne-Marie Jutant, Marie-Camille Chaumais, Stéphane Bouchet, Benjamin Manéglier, Mathieu Molimard, Philippe Rousselot, Olivier Sitbon, Gérald Simonneau, David Montani, Marc Humbert, Christophe Guignabert
European Respiratory Journal Sep 2016, 48 (suppl 60) OA262; DOI: 10.1183/13993003.congress-2016.OA262
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