Figures
- FIGURE 1
Sample selection. IPF: idiopathic pulmonary fibrosis; ICD-9-CM: International Classification of Diseases, Ninth Revision, Clinical Modification.
- FIGURE 2
Annual prevalence and incidence rate of idiopathic pulmonary fibrosis in the commercially insured population aged 18–64 years, overall and by subgroup, 2005–2010: a) primary cohort, b) broad case subgroup and c) narrow case subgroup.
- FIGURE 3
Annual incidence rate of idiopathic pulmonary fibrosis in the commercially insured population aged 18–64 years across age groups, overall and by subgroup, 2005–2010: a) primary cohort, b) broad case subgroup and c) narrow case subgroup.
Tables
- TABLE 1
Demographics of enrolees in 2010 and incident patients with idiopathic pulmonary fibrosis (IPF), overall and by subgroup
Optum enrolees in 2010 IPF cohort Primary cohort incident patients Broad case subgroup Narrow case subgroup Subjects n 9 375 020 4206 2670 1685 Age (mean) at diagnosis years 41.7 53.4 52.7 53.6 Age at diagnosis years 18–34 31.8 5.3 6.3 4.7 35–44 23.1 11.6 13.0 12.1 45–54 25.4 26.7 27.0 25.6 55–64 19.8 56.4 53.7 57.6 Female 51.6 50.6 51.7 52.7 Census region New England 17.9 18.2 16.9 17.6 Middle Atlantic 13.7 15.5 17.9 18.2 South Atlantic 20.7 23.1 23.9 24.7 East South Central 2.7 3.1 3.3 3.6 West South Central 14.9 15.9 15.7 14.1 East North Central 11.0 10.3 9.1 9.7 West North Central 8.0 5.0 4.6 4.3 Mountain 6.0 5.4 5.2 4.6 Pacific 5.2 3.3 3.5 3.2 Other/unknown 0.0 0.2 0.2 0.1 Data are presented as %, unless otherwise stated.
- TABLE 2
Prevalence of comorbidities during the 1 year before idiopathic pulmonary fibrosis (IPF) diagnosis
IPF cohort Primary cohort incident patients Broad case subgroup Narrow case subgroup Subjects n 4206 2670 1685 Pulmonary and respiratory diseases Chronic obstructive pulmonary disease 28.7 26.1 30.7 Pneumonia 21.4 18.9 24.6 Acute bronchitis and bronchiolitis 18.8 18.1 19.8 Asthma 18.6 18.4 20.0 Sleep apnoea 8.5 7.8 8.6 Pulmonary embolism 2.8 2.7 3.4 Pulmonary hypertension 2.7 2.4 3.2 Lung cancer/bronchogenic carcinoma 2.7 2.7 4.1 Influenza 1.3 1.3 1.6 Cardiovascular diseases Coronary artery disease (exclusive of myocardial infarction) 15.7 14.5 16.4 Heart failure 9.4 7.9 9.1 Cerebrovascular disease 5.6 5.5 6.0 Atrial fibrillation 4.2 3.9 4.1 Myocardial infarction 2.8 2.8 2.9 Acute coronary syndrome 2.2 2.4 2.4 Deep vein thrombosis 1.1 0.9 1.4 Other diseases Diabetes 18.2 17.6 18.0 Fatigue 17.5 17.9 19.6 Gastro-oesophageal reflux disease 16.9 16.5 18.5 Depression 10.2 10.4 11.3 Obesity 5.3 5.2 4.8 Rib fractures 0.6 0.4 0.7 Data are presented as %, unless otherwise stated.
- TABLE 3
Factors associated with incidence of idiopathic pulmonary fibrosis (primary cohort)
Incidence rate# (95% CI)¶ Adjusted incidence rate ratio (95% CI) All enrolees 6.1 (5.9–6.4) Age years+ 18–34 1.1 (1.0–1.3) 0.06§ (0.05–0.06) 35–44 2.6 (2.4–2.9) 0.15§ (0.14–0.16) 45–54 6.4 (6.0–6.9) 0.36§ (0.34–0.39) 55–64 19.3 (18.4–20.3) 1.00 (Reference) Sex Male 6.4 (6.1–6.7) 1.08 (1.02–1.15) Female 5.9 (5.6–6.2) 1.00 (Reference) Census region New England 5.4 (5.0–5.9) 0.80§ (0.71–0.90) Middle Atlantic 6.3 (5.7–6.9) 1.00 (0.89–1.12) South Atlantic 7.9 (7.3–8.5) 1.22§ (1.09–1.37) East South Central 8.2 (6.7–9.8) 1.07 (0.88–1.30) West South Central 6.1 (5.5–6.7) 1.22§ (1.08–1.37) East North Central 6.6 (5.9–7.3) 1.00 (Reference) West North Central 4.5 (3.8–5.2) 0.74§ (0.63–0.87) Mountain 5.4 (4.6–6.2) 0.79§ (0.68–0.93) Pacific 4.0 (3.2–4.9) 0.91 (0.76–1.09) Other/unknown 9.1 (2.8–25.2) 1.72 (0.64–4.61) #: incidence rate reported as number of new cases per 100 000 person-years using data from 2005 to 2010; ¶: estimated based on Poisson distribution; +: age at entry into the database; §: statistically significant at p<0.05.
Disclosures
Supplementary material
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