FIGURE 5 Correlation between lipid mediators in bronchoalveolar lavage fluid (BALF) with lung function, mRNA, neutrophils and goblet cells. a) The correlation between lung function parameters (forced expiratory volume in 1 s (FEV1) and FEV1/forced expiratory volume (FVC)) versus the concentrations of EpOMEs and DiHOMEs in female COPD smokers (PLS inner relation, r=0.87, p=0.0009, n=10). b) The correlation of FEV1 versus mRNA related to the EpOME and DiHOME lipid mediators (EPHX1, EPHX2, CYP1A2, CYP2C, CYP2J, CYP3A4 and CYP2E1) of a subset of the female COPD smokers group (PLS inner relation, r=0.96, p=0.003, n=6). c) The correlation between neutrophil abundance in BALF and 9,10,13-TriHOME (PLS inner relation, r=0.77, p=0.005, n=11). d) The correlation between goblet cell abundance versus the 2 EpOME lipid mediators (leukotoxin and isoleukotoxin; PLS inner relation, r=0.72, p=0.03, n=9). Lipid mediator nomenclature is as follows: EpOMEs=9(10)-EpOME (9[10]-epoxy-12Z-octadecenoic acid) and 12(13)-EpOME (12[13]epoxy-9Z-octadecenoic acid); DiHOMEs=9,10-DiHOME (9[10]-dihydroxy-12Z-octadecenoic acid) and 12,13-DiHOME (12[13]-dihydroxy-12Z-octadecenoic acid); 9,10,13-TriHOME (9,10,13-trihydroxy-11E-octadecenoic acid).