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First independent evaluation of QuantiFERON-TB Plus performance

Lucia Barcellini, Emanuele Borroni, James Brown, Enrico Brunetti, Luigi Codecasa, Federica Cugnata, Paola Dal Monte, Clelia Di Serio, Delia Goletti, Giulia Lombardi, Marc Lipman, Paola M.V. Rancoita, Marina Tadolini, Daniela M. Cirillo
European Respiratory Journal 2016 47: 1587-1590; DOI: 10.1183/13993003.02033-2015
Lucia Barcellini
1Emerging Bacterial Pathogens Unit, Division of Immunology and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy
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Emanuele Borroni
1Emerging Bacterial Pathogens Unit, Division of Immunology and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy
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James Brown
2Royal Free London NHS Trust and UCL Respiratory, Division of Medicine, University College London, UK
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Enrico Brunetti
3Dept of Infectious Diseases, San Matteo Hospital Foundation–University of Pavia, Pavia, Italy
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Luigi Codecasa
4Regional TB Reference Centre, Villa Marelli Institute/Niguarda Ca’ Granda Hospital, Milan, Italy
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Federica Cugnata
5University Centre of Statistics for Biomedical Sciences (CUSSB), Vita-Salute San Raffaele University, Milan, Italy
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Paola Dal Monte
6Microbiology Unit – Dept of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, Bologna, Italy
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Clelia Di Serio
5University Centre of Statistics for Biomedical Sciences (CUSSB), Vita-Salute San Raffaele University, Milan, Italy
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Delia Goletti
7Translational Research Unit, Epidemiology Dept, National Institute for Infectious Diseases, Rome, Italy
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Giulia Lombardi
6Microbiology Unit – Dept of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, Bologna, Italy
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Marc Lipman
2Royal Free London NHS Trust and UCL Respiratory, Division of Medicine, University College London, UK
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Paola M.V. Rancoita
5University Centre of Statistics for Biomedical Sciences (CUSSB), Vita-Salute San Raffaele University, Milan, Italy
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Marina Tadolini
8Infectious Diseases Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy
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Daniela M. Cirillo
1Emerging Bacterial Pathogens Unit, Division of Immunology and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy
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  • For correspondence: cirillo.daniela@hsr.it
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Tables

  • TABLE 1

    QuantiFERON-TB Plus (QFT-Plus) performance characteristics in different study groups

    FrequencyQFT-Plus resultPositive results in each tubeIFN-γ concentration¶ IU·mL−1TB2−TB1 IU·mL−1
    IndeterminateNegative#Positive#TB1TB2TB1TB2
    Low-risk controls1060103 (97.17)3 (2.83)210.1 (0.09–0.13)0.11 (0.09–0.13)0 (−0.01–0.01)
    Active TB119314 (12.07)102 (87.93)961012.09 (0.83–6.52)2.88 (1–7.89)0.14 (−0.13–0.79)
    Sex
     Male7217 (9.86)64 (90.14)59642.08 (0.86–6.38)2.91 (1.17–7.62)0.23 (−0.14–0.88)
     Female4727 (15.56)38 (84.44)37372.09 (0.71–7.03)2.85 (0.88–7.80)0.11 (−0.11–0.50)
    Smear
     Negative65112 (18.75)52 (81.25)51522.12 (0.89–9.51)2.69 (1.01–9.66)0.05 (−0.17–0.55)
     Positive5422 (3.85)50 (96.15)45492 (0.67–6.04)3.26 (0.92–6.31)0.29 (0–1.16)
    Localisation
     PTB7939 (11.84)67 (88.16)62661.93 (0.57–6.04)2.82 (0.75–6.22)0.26 (−0.12–0.80)
     EPTB4005 (12.5)35 (87.5)34352.29 (1.23–10)2.95 (1.15–10)0.06 (−0.17–0.46)
    BCG
     Negative602 (33.33)4 (66.67)441.15 (0.33–1.86)1.47 (0.4–2.75)0.07 (0.01–0.44)
     Positive5404 (7.41)50 (92.59)44502.01 (0.9–6.57)2.79 (1.02–8.2)0.14 (−0.20–0.65)
    • Data are presented as n, n (%) or median (interquartile range). IFN: interferon; TB: tuberculosis; PTB: pulmonary tuberculosis; EPTB: extrapulmonary tuberculosis; BCG: bacille Calmette–Guérin. #: percentages are based on the total number of valid tests, excluding indeterminate results.

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First independent evaluation of QuantiFERON-TB Plus performance
Lucia Barcellini, Emanuele Borroni, James Brown, Enrico Brunetti, Luigi Codecasa, Federica Cugnata, Paola Dal Monte, Clelia Di Serio, Delia Goletti, Giulia Lombardi, Marc Lipman, Paola M.V. Rancoita, Marina Tadolini, Daniela M. Cirillo
European Respiratory Journal May 2016, 47 (5) 1587-1590; DOI: 10.1183/13993003.02033-2015

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First independent evaluation of QuantiFERON-TB Plus performance
Lucia Barcellini, Emanuele Borroni, James Brown, Enrico Brunetti, Luigi Codecasa, Federica Cugnata, Paola Dal Monte, Clelia Di Serio, Delia Goletti, Giulia Lombardi, Marc Lipman, Paola M.V. Rancoita, Marina Tadolini, Daniela M. Cirillo
European Respiratory Journal May 2016, 47 (5) 1587-1590; DOI: 10.1183/13993003.02033-2015
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