Figures
- FIGURE 1
High interleukin-22 receptor subunit 1 (IL-22R1) expression is associated with primary nonsmall cell lung cancer (NSCLC) and decreases overall survival. IL-22R1 RNA expression was detected by quantitative reverse transcriptase PCR and normalised to reference genes (β-actin and Hprt1) for 81 surgical patients with a histological diagnosis of primary NSCLC. a) IL-22R1 mRNA expression in tumour (T) tissues and nontumour (NT) tissue counterparts was assessed in paired tissues obtained from NSCLC patients. Data are shown as mean±sem. The p-value was calculated by Wilcoxon signed-rank test. b) Kaplan–Meier plots of overall survival in 73 NSCLC patients according to IL-22R1 gene expression levels in tumour. The optimal cut-off point to dichotomise patients into low IL-22R1 expression and high IL-22R1 expression was established by the X-tile algorithm (cut-off value=0.297, 42nd percentile of IL-22R1 expression in tumours). The p-value was calculated by the log-rank test. c) Forest plot of the hazard ratio (HR) for IL-22R1 expression and overall survival by cohort, based on data obtained by the PrognoScan, PROGgeneV2, Kaplan–Meier (KM) Plotter and SurvExpress platforms. d) Prognostic value of IL-22R1 expression in 1926 NSCLC patients through the Kaplan–Meier Plotter database. IL-22R1 tumour expression was dichotomised into high versus low according to median expression.
